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SAE0022

Phosphoglucomutase 1 human

Name: Phosphoglucomutase 1 human
Brand: SIGMA

lyophilized powder, recombinant, expressed in E. coli

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Informacje o tej pozycji

UNSPSC Code:

12352204

NACRES:

NA.54

Numer WE:

5.4.2.2 (BRENDA, IUBMB)

Specific activity:

≥400 units/mg protein

Assay:

≥95% (PAGE)

Recombinant:

expressed in E. coli

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Właściwości

recombinant

expressed in E. coli

Quality Segment

200

description

PGM1 isoform sequence with a predicted molecular mass of 61.3kDa.

assay

≥95% (PAGE)

form

lyophilized powder

specific activity

≥400 units/mg protein

shipped in

dry ice

storage temp.

−20°C

Opis

General description

Phosphoglucomutase-1 (PGM1) is an evolutionarily conserved enzyme[1] that belongs to the phosphohexose mutase family.[2] It is the major isoform of PGM in skeletal muscle and most other tissues.[3] The PGM1 gene is mapped to human chromosome 1p31.3.[4]

Biochem/physiol Actions

Phosphoglucomutase-1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P).[1] It regulates carbohydrate metabolism, energy production, and protein N-glycosylation.[2] PGM1 participates in the biosynthesis of nucleotide sugars required for glycan biosynthesis.[5] Variation in the PGM1 gene leads to PGM1 deficiency, which is considered an inherited metabolic disorder in humans.[2][5] PGM1 deficiency causes autosomal recessive diseases such as glycogen storage disease type XIV and congenital disorder of protein N-glycosylation.[5] Affected patients show multiple disease phenotypes, reflecting the central role of the enzyme in glucose homeostasis. The influence of PGM1 deficiency on protein glycosylation patterns is also widespread.[1][6] PGM1 acts as a metabolic tumor suppressor.[4]

Physical form

Supplied as a lyophilized powder containing tris-buffered saline, EDTA, DTT and stabilizer.

Other Notes

One unit will convert 1.0 μmole of α-D-Glucose-1-Phosphate to α-D-Glucose-6-phosphate per minute at pH 7.4 at 30 °C.

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Ta pozycja	SRP8010	SRE0069	P3397
Sigma-Aldrich SAE0022 Phosphoglucomutase 1 human	Sigma-Aldrich SRP8010 GPX1 human	Sigma-Aldrich SRE0069 Phosphoglucomutase from rabbit muscle	Sigma-Aldrich P3397 Phosphoglucomutase from rabbit muscle
assay ≥95% (PAGE)	assay >90% (SDS-PAGE)	assay -	assay -
specific activity ≥400 units/mg protein	specific activity -	specific activity ≥100 units/mg protein	specific activity ≥100 units/mg protein
form lyophilized powder	form lyophilized	form lyophilized powder	form ammonium sulfate suspension
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant -	recombinant -
shipped in dry ice	shipped in wet ice	shipped in wet ice	shipped in wet ice
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C

Klasa składowania

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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