S9066

SKF-89976A

>98% (HPLC), solid

• Synonim(y): 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
• Wzór empiryczny (zapis Hilla): C₂₂H₂₅NO₂ · HCl
• Numer CAS: 85375-15-1
• Masa cząsteczkowa: 371.90
• NACRES: NA.77
• PubChem Substance ID: 24278796
• UNSPSC Code: 12352200
• MDL number: MFCD01321071
• Assay: >98% (HPLC)
• Form: solid

Właściwości

• assay: >98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: soluble 20 mg/mL, H₂O: insoluble
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: Cl[H].OC(=O)C1CCCN(CC\C=C(/c2ccccc2)c3ccccc3)C1
• InChI: 1S/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H
• InChI key: SNGGBKYQZVAQKA-UHFFFAOYSA-N
• Gene Information: human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539) ; rat ... Slc6a1(79212), Slc6a12(50676)

Opis

Application

SKF-89976A was used to study the role of adenosine receptors in uptake of GABA transport.^4,5

Biochem/physiol Actions

GABA transporter type 1 (GAT-1) inhibitor that crosses the blood brain barrier.

SKF-89976A contains a cyclic amino acid with lipophilic moiety that enables the compound to cross the blood-brain barrier.^1,2 It decreases the excitotoxic swelling of chick retina cells by blocking the glutamate-induced GABA release.³

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)