S6508

Sodium orthovanadate

synthetic (organic), ≥90% (titration), protein tyrosine phosphatase inhibitor, crystalline powder

• Synonim(y): Trisodium vanadate
• Wzór liniowy: Na₃VO₄
• Numer CAS: 13721-39-6
• Masa cząsteczkowa: 183.91
• NACRES: NA.77
• PubChem Substance ID: 24899708
• UNSPSC Code: 12352200
• EC Number: 237-287-9
• MDL number: MFCD00003511
• Assay: ≥90% (titration)
• Form: crystalline powder

Właściwości

• Nazwa produktu: Sodium orthovanadate, ≥90% (titration)
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥90% (titration)
• form: crystalline powder
• reaction suitability: reagent type: catalyst; core: vanadium
• color: white to off-white
• mp: 850-866 °C (lit.)
• solubility: H₂O: soluble
• SMILES string: [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O
• InChI: 1S/3Na.4O.V/q3*+1;;3*-1;
• InChI key: IHIXIJGXTJIKRB-UHFFFAOYSA-N

Opis

Application

Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.²⁶ It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.²⁷

Biochem/physiol Actions

Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP₃)-induced Ca²⁺ release from endocrine cells and blocks IP₃ binding to its receptor in brain tissue.

Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.²⁴ In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.²⁵

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Klasa składowania: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves