S3065

SC 19220

≥98% (HPLC), solid

• Synonim(y): 2-Acetylhydrazide 10(11H)-carboxylic acid, 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid
• Wzór empiryczny (zapis Hilla): C₁₆H₁₄N₃O₃Cl
• Numer CAS: 19395-87-0
• Masa cząsteczkowa: 331.75
• NACRES: NA.77
• PubChem Substance ID: 24278701
• UNSPSC Code: 12352200
• MDL number: MFCD02259329
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• assay: ≥98% (HPLC)
• form: solid
• color: white
• mp: 190-191 °C (lit.)
• solubility: DMSO: soluble 10 mg/mL, H₂O: insoluble
• SMILES string: CC(=O)NNC(=O)N1Cc2ccccc2Oc3ccc(Cl)cc13
• InChI: 1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)
• InChI key: KNURFLJTOUGOOQ-UHFFFAOYSA-N
• Gene Information: human ... PTGER1(5731) ; rat ... Ptger1(25637)

Opis

Application

SC 19220 was used to study the role of prostaglandin E₂ in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.

Biochem/physiol Actions

EP₁ Prostanoid receptor antagonist

SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE₂ in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E₂ and F_2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)