RAB1050

Human Galectin-8 ELISA Kit

for cell culture supernatants, plasma, and serum samples

• Kod UNSPSC: 41116158
• NACRES: NA.32

Właściwości

• reaktywność gatunkowa: human
• opakowanie: kit of 96 wells (12 strips x 8 wells)
• metody: ELISA: suitable
• moc wejściowa: sample type plasma; sample type serum sample(s); sample type cell culture supernatant(s)
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 0.16 ng/ml
• metoda wykrywania: colorimetric
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• informacje o genach: human ... LGALS8(3964)

Opis

Opis ogólny

This ELISA antibody pair detects Human Galectin-8 (LGALS8)

Zastosowanie

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Działania biochem./fizjol.

Galectin-8 (Gal-8) is a member of “tandem-repeat” galectin family, possesses two carbohydrate binding domains linked by a short peptide. The short peptide accounts for Gal-8 cell adhesion and downstream signalling. Tumor cells, as well as normal tissues, express Gal-8. The expression level of Gal-8 is higher in multiple myeloma conditions and enhances adhesion to vascular endothelium. Galectin-8 binds to integrin selectively and inhibits cell adhesion and promotes apoptosis. Gal-8 interacts with integrin alpha and regulates neutrophil adhesion to endothelial cells and migration. Gal-8 ligand binds to cluster of differentiation 44 (CD44) and causes an inflammatory response in rheumatoid arthritis. Overexpression of Gal-8 plays a key role in metastasis of prostate cancer and cell survival by causing rearrangement of the cytoskeleton and E-cadherin expression.

Inne uwagi

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS05
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H290
• Zwroty wskazujące środki ostrożności: P234 - P390
• Klasyfikacja zagrożeń: Met. Corr. 1
• Kod klasy składowania: 8A - Combustible corrosive hazardous materials
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable