R8657

Razoxane

>98% (HPLC)

• Synonim(y): (±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane, (±)-1,2-Bis(3,5-dioxopiperazinyl)propane, 1,2-Bis(3,5-dioxo-1-piperazinyl)propane, 4,4′-Propylenebis(2,6-piperazinedione), ICI 59118, ICRF 159, NSC 129943, Razoxin, Tepirone, Troxozone
• Wzór empiryczny (zapis Hilla): C₁₁H₁₆N₄O₄
• Numer CAS: 21416-67-1
• Masa cząsteczkowa: 268.27
• NACRES: NA.77
• PubChem Substance ID: 329824039
• UNSPSC Code: 12352200
• EC Number: 244-379-2
• MDL number: MFCD00430424
• Assay: >98% (HPLC)
• Form: solid

Właściwości

• assay: >98% (HPLC)
• form: solid
• solubility: DMSO: 40 mg/mL
• storage temp.: room temp
• SMILES string: CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
• InChI: 1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)
• InChI key: BMKDZUISNHGIBY-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.

Razoxane is clinically active against angiogenesis and metastasis; inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor).

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable