R3405

RP-107

≥98% (HPLC), solid

• Synonim(y): 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
• Wzór empiryczny (zapis Hilla): C₁₆H₁₇N₃O
• Numer CAS: 496864-15-4
• Masa cząsteczkowa: 267.33
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824024
• MDL number: MFCD04973541
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Właściwości

• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CCCCc1c([nH]c2nccnc12)-c3ccc(O)cc3
• InChI: 1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
• InChI key: PRIGRJPRGZCFAS-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel.

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC₅₀ = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves