PZ0281

PF-05212384

≥98% (HPLC)

• Synonim(y): 1-(4-((4-(Dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea, Gedatolisib, PKI-587
• Wzór empiryczny (zapis Hilla): C₃₂H₄₁N₉O₄
• Numer CAS: 1197160-78-3
• Masa cząsteczkowa: 615.73
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 0.5 mg/mL, clear (warmed)
• storage temp.: room temp
• SMILES string: N6(CCOCC6)c1nc(nc(n1)c3ccc(cc3)NC(=O)Nc4ccc(cc4)C(=O)N5CCC(CC5)N(C)C)N2CCOCC2
• InChI: 1S/C32H41N9O4/c1-38(2)27-11-13-39(14-12-27)29(42)24-5-9-26(10-6-24)34-32(43)33-25-7-3-23(4-8-25)28-35-30(40-15-19-44-20-16-40)37-31(36-28)41-17-21-45-22-18-41/h3-10,27H,11-22H2,1-2H3,(H2,33,34,43)
• InChI key: DWZAEMINVBZMHQ-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

PF-05212384, also known as PKI-587 and Gedatolisib, is a dual phosphatidylinositol-3-kinase (PI3K) / mammalian target of rapamycin (mTOR) inhibitor. PKI-587 potently inhibited class I PI3Ks (IC₅₀ vs PI3K-α = 0.4 nM), PI3K-α mutants, and mTOR. PF-05212384 inhibited growth of 50 diverse human tumor cell lines at IC₅₀s <100 nM and has been in clinical trials in patients with advanced solid tumors. PF-05212384 has also been found to sensitize cells to radiation.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable