PZ0193

Axitinib

≥98% (HPLC), powder, tyrosine kinase inhibitor

• Synonim(y): AG-013736, N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
• Wzór empiryczny (zapis Hilla): C₂₂H₁₈N₄OS
• Numer CAS: 319460-85-0
• Masa cząsteczkowa: 386.47
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823767
• NACRES: NA.77
• MDL number: MFCD09837898
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Axitinib, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥8 mg/mL
• storage temp.: room temp
• SMILES string: CNC(=O)c1ccccc1Sc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2
• InChI: 1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
• InChI key: RITAVMQDGBJQJZ-FMIVXFBMSA-N
• Gene Information: human ... FLT1(2321), FLT4(2324), KDR(3791)

Opis

Application

Axitinib has been used as a vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor (TKI) to study its effect on renal cancer cell proliferation in vitro. It has also been used to inhibit anterior mesenteric artery (AMA) angiogenesis in dechlorinated embryos maintained in conditioned water (CW).

Biochem/physiol Actions

Axitinib (AG-013736) is an orally available, potent (picomolar) and selective tyrosine kinase inhibitor that blocks VEGF receptors 1, 2 and 3. The drug blocks VEGF-mediated endothelial cell survival, tube formation, and downstream signaling through endothelial nitric oxide synthase, Akt and extracellular signal-regulated kinase.

Orally available, potent and selective inhibitor of VEGF receptors 1, 2 and 3

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07,GHS09
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H400
• Ostrzeżenia: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable