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PZ0185

Sigma-Aldrich

PF-431396 hydrate

≥98% (HPLC)

Synonim(y):

N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide hydrate

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About This Item

Wzór empiryczny (zapis Hilla):
C22H21F3N6O3S · xH2O
Numer CAS:
717906-29-1
Masa cząsteczkowa:
506.50 (anhydrous basis)
Numer MDL:
MFCD21608515
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
329823759
NACRES:
NA.77

Próba

≥98% (HPLC)

Postać

powder

kolor

off-white to blue-gray

rozpuszczalność

DMSO: ≥10 mg/mL

temp. przechowywania

2-8°C

ciąg SMILES

O.CN(c1ccccc1CNc2nc(Nc3ccc4NC(=O)Cc4c3)ncc2C(F)(F)F)S(C)(=O)=O

InChI

1S/C22H21F3N6O3S.H2O/c1-31(35(2,33)34)18-6-4-3-5-13(18)11-26-20-16(22(23,24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17;/h3-9,12H,10-11H2,1-2H3,(H,29,32)(H2,26,27,28,30);1H2

Klucz InChI

XSXCARUUZVMRGX-UHFFFAOYSA-N

Powiązane kategorie

Zastosowanie

PF-431396 hydrate has been used as a dual inhibitor of proline-rich tyrosine kinase 2 (PYK2) / focal adhesion kinase (FAK) inhibitor to study its effects on phosphorylation of Yes-associated protein (YAP) at Ser127 and steady state of transcriptional coactivator with PDZ-binding motif (TAZ) . It has also been used as a PYK2/FAK inhibitor to study its effects on protein kinase A activation in human sperm samples .

Działania biochem./fizjol.

PF-431396 is a potent inhibitor of PYK2 and FAK kinases (IC50 = 11 and 1.5 nM, respectively). PF-431396 increases bone formation and protects against bone loss in ovariectomized rats.

Cechy i korzyści

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Piktogramy

Skull and crossbones
GHS06

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H301,H319

Klasyfikacja zagrożeń

Acute Tox. 3 Oral - Eye Irrit. 2

Kod klasy składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Odwiedź Bibliotekę dokumentów

Zhen Liu et al.
Neuroreport, 31(10), 754-761 (2020-05-27)
The aim of this study was to investigate the effects of histone deacetylase-6 (HDAC6) on the functional and pathological changes of the amyloid beta (Aβ)-induced cognitive dysfunction rats by regulating protein tyrosine kinase 2 beta (PTK2B). Ninety Sprague Dawley rats
Seyedeh Fatemeh Razavipour et al.
Nature communications, 15(1), 5152-5152 (2024-06-18)
In many cancers, a stem-like cell subpopulation mediates tumor initiation, dissemination and drug resistance. Here, we report that cancer stem cell (CSC) abundance is transcriptionally regulated by C-terminally phosphorylated p27 (p27pT157pT198). Mechanistically, this arises through p27 co-recruitment with STAT3/CBP to
Jialie Luo et al.
Immunity, 56(7), 1533-1547 (2023-06-25)
The crosstalk between the immune and neuroendocrine systems is critical for intestinal homeostasis and gut-brain communications. However, it remains unclear how immune cells participate in gut sensation of hormones and neurotransmitters release in response to environmental cues, such as self-lipids
Evidence for the involvement of proline-rich tyrosine kinase 2 in tyrosine phosphorylation downstream of protein kinase A activation during human sperm capacitation
Battistone M A, et al.
Molecular Human Reproduction, 20(11), 1054-1066 (2014)
PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein
Kedan A, et al.
Cell Death & Disease, 9(10), 1-15 (2018)
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