Przejdź do zawartości
Merck

Kluczowe dokumenty

Wyświetl całą dokumentację

Przejdź do

PZ0178

PHA 767491 hydrochloride

≥98% (HPLC)

Synonim(y):

1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride, 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride, PHA-00767491 hydrochloride

Zaloguj się, aby wyświetlić ceny organizacyjne i kontraktowe.

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C12H11N3O · xHCl
Numer CAS:
845538-12-7
Masa cząsteczkowa:
213.24 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
329823752
UNSPSC Code:
51111800
MDL number:
MFCD11519962
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

off-white to yellow

solubility

H2O: >25 mg/mL

SMILES string

Cl.O=C1NCCc2[nH]c(cc12)-c3ccncc3

InChI

1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H

InChI key

IMVNFURYBZMFDZ-UHFFFAOYSA-N

Application

PHA 767491 hydrochloride has been used to study its effect on estrogen-induced DNA damage. It has also been used in western blot analysis and to study the S9.6 nuclear signal in HeLa cells.

Biochem/physiol Actions

PHA 767491 serves as a potential anticancer drug. It shows an ameliorating effect against acute myeloid leukemia, colon and breast cancer models. PHA 767491 possesses anti proliferating and apoptotic effect.
PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9.
PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites.
Ta strona może zawierać tekst przetłumaczony maszynowo.

Klasa składowania

11 - Combustible Solids

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Dokumenty section.

Proszę o kontakt, jeśli potrzebna jest pomoc Obsługa Klienta

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Questions

  1. 시약 보관 온도 문의드립니다. H2O에 녹인 후에 -20'C에 보관하면 되는걸까요?

    1 answer

    1. Unfortunately, the solution stability of this product has not been determined. However, historical information on a previously deleted option indicates that solutions in water may be stored for up to 1 month and solutions in DMSO may be stored for up to 6 months at - 20°C, in aliquots. Avoid repeated freeze/thaw cycles.

      Helpful?

Reviews

No rating value

Active Filters