PZ0016

Dofetilide

≥98% (HPLC), powder, hERG channel blocker

• Synonim(y): N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide, UK-68798
• Wzór empiryczny (zapis Hilla): C₁₉H₂₇N₃O₅S₂
• Numer CAS: 115256-11-6
• Masa cząsteczkowa: 441.56
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823685
• NACRES: NA.77
• MDL number: MFCD00869707
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Dofetilide, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• storage temp.: room temp
• SMILES string: CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc2ccc(NS(C)(=O)=O)cc2
• InChI: 1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
• InChI key: IXTMWRCNAAVVAI-UHFFFAOYSA-N
• Gene Information: human ... KCNH2(3757)

Opis

Biochem/physiol Actions

Dofetilide is a Class III antiarrhythmic and hERG channel blocker. Dofetilide selectively blocks the rapid component of the delayed rectifier outward potassium current (IKr).

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS09
• signalword: Danger
• hcodes: H360,H373,H411
• pcodes: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Hazard Classifications: Aquatic Chronic 2 - Repr. 1B - STOT RE 2
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable