P5333
Pleiotrophin human
≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
Synonim(y):
HARP, HB-GAM, Heparin affinity regulatory peptide, Heparin-binding growth factor, Heparin-binding growth-associated molecule, PTN
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Polecane produkty
pochodzenie biologiczne
human
Poziom jakości
rekombinowane
expressed in baculovirus infected Sf21 cells
Próba
≥97% (SDS-PAGE)
Postać
lyophilized powder
masa cząsteczkowa
predicted mol wt 15.3 kDa
opakowanie
pkg of 50 μg
warunki przechowywania
avoid repeated freeze/thaw cycles
metody
cell culture | mammalian: suitable
zanieczyszczenia
endotoxin, tested
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
human ... PTN(5764)
Opis ogólny
Pleiotrophin (PTN) is a multifunctional growth factor. The protein coded by the PTN gene is a member of the heparin-binding cytokines family. This gene is located on human chromosome 7. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSF-1). This gene is highly expressed in brain, uterus, gut, muscle, lung and skin. Pleiotrophin mRNA is expressed in osteoblasts, chondrocytes, tumor cells, fibroblasts, astrocytes and Schwann cells.
Zastosowanie
PTN is active in growth and development, and has mitogenic and neurite outgrowth activity. The gene for pleiotrophin is highly expressed in brain, uterus, gut, muscle, lung, and skin tissues
Działania biochem./fizjol.
Pleiotrophin participates in growth and development. Pleiotrophin is mitogenic and displays neurite outgrowth activity. It stimulates tumor angiogenesis. There is extraordinary conservation between the amino acid sequences of bovine, human, and rat pleiotrophin.
Pleiotrophin may be the first member of a family of developmentally regulated cytokines. It is active in growth and development and the pleiotrophin gene is highly expressed in brain, uterus, gut, muscle, lung, and skin. Pleiotrophin mRNA is expressed in osteoblasts, chondrocytes, fibroblasts, astrocytes, Schwann cells, and tumor cells. Pleiotrophin is mitogenic and displays neurite outgrowth activity. It stimulates tumor angiogenesis. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSF-1). There is extraordinary conservation between the amino acid sequences of bovine, human, and rat pleiotrophin.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Komentarz do analizy
The activity is measured in culture by the ability to enhance neurite outgrowth of cerebral cortical neurons from rat embryos.
This page may contain text that has been machine translated.
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Pleiotrophin expression during odontogenesis.
Erlandsen H, et al.
The Journal of Histochemistry and Cytochemistry, 60(5), 366-375 (2012)
Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus.
Gonzalez-Castillo C, et al.
Frontiers in Cellular Neuroscience, 8, 443-443 (2015)
Characterization of the human pleiotrophin gene. Promoter region and chromosomal localization.
Li Y S, et al.
The Journal of Biological Chemistry, 267(36), 26011-26016 (1992)
H Muramatsu et al.
Biochemical and biophysical research communications, 177(2), 652-658 (1991-06-14)
Midkine (MK) is the product of a retinoic acid responsive gene, MK, and is the initial member of a new family of heparin binding factors. Recombinant MK produced by an L-cell clone transfected with an MK cDNA was purified to
Heather A Himburg et al.
Nature medicine, 16(4), 475-482 (2010-03-23)
Hematopoietic stem cell (HSC) self-renewal is regulated by both intrinsic and extrinsic signals. Although some of the pathways that regulate HSC self-renewal have been uncovered, it remains largely unknown whether these pathways can be triggered by deliverable growth factors to
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
Skontaktuj się z zespołem ds. pomocy technicznej