P5178

Phenobarbital sodium salt

• Synonim(y): 5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt, 5-Ethyl-5-phenylbarbituric acid sodium salt, Luminal sodium salt, Sodium 5-ethyl-5-phenylbarbiturate
• Wzór empiryczny (zapis Hilla): C₁₂H₁₁N₂NaO₃
• Numer CAS: 57-30-7
• Masa cząsteczkowa: 254.22
• Beilstein: 3802044
• Numer WE: 200-322-3
• Numer MDL: MFCD00036211
• Kod UNSPSC: 12352202
• Identyfikator substancji w PubChem: 24898608
• NACRES: NA.77

Właściwości

• Formularz: powder
• kontrola substancji: USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• rozpuszczalność: H₂O: 1 g/mL; ethanol: 100 mg/mL
• inicjator: Bayer
• ciąg SMILES: [Na+].CCC1(C(=O)NC([O-])=NC1=O)c2ccccc2
• InChI: 1S/C12H12N2O3.Na/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;/h3-7H,2H2,1H3,(H2,13,14,15,16,17);/q;+1/p-1
• Klucz InChI: WRLGYAWRGXKSKG-UHFFFAOYSA-M

Opis

Zastosowanie

Phenobarbital sodium salt has been used:

• to anesthetize mice for inducing ischemia-reperfusion injury[1]
• as a positive control for the activation of constitutive androstane receptor (CAR)[2]
• in bioluminescent yeast bioreporters (BLYAS) assay[3]

Działania biochem./fizjol.

Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation.[4] It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus.[5]

Sedative; hypnotic; anticonvulsant; enhances GABAergic activity.

Cechy i korzyści

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Dopamine and Norepinephrine Metabolism and GABAA Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H301,H317,H351
• Zwroty wskazujące środki ostrożności: P202 - P261 - P264 - P280 - P301 + P310 - P302 + P352
• Klasyfikacja zagrożeń: Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges