P5178

Phenobarbital sodium salt

GABAA receptor activator, powder

• Synonim(y): 5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt, 5-Ethyl-5-phenylbarbituric acid sodium salt, Luminal sodium salt, Sodium 5-ethyl-5-phenylbarbiturate
• Wzór empiryczny (zapis Hilla): C₁₂H₁₁N₂NaO₃
• Numer CAS: 57-30-7
• Masa cząsteczkowa: 254.22
• NACRES: NA.77
• PubChem Substance ID: 24898608
• UNSPSC Code: 12352202
• EC Number: 200-322-3
• MDL number: MFCD00036211
• Beilstein/REAXYS Number: 3802044
• Form: powder

Właściwości

• Nazwa produktu: Phenobarbital sodium salt,
• form: powder
• Quality Segment: 200
• drug control: USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland
• solubility: H₂O: 1 g/mL, ethanol: 100 mg/mL
• originator: Bayer
• SMILES string: [Na+].CCC1(C(=O)NC([O-])=NC1=O)c2ccccc2
• InChI: 1S/C12H12N2O3.Na/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;/h3-7H,2H2,1H3,(H2,13,14,15,16,17);/q;+1/p-1
• InChI key: WRLGYAWRGXKSKG-UHFFFAOYSA-M

Opis

Application

Phenobarbital sodium salt has been used:

• to anesthetize mice for inducing ischemia-reperfusion injury
• as a positive control for the activation of constitutive androstane receptor (CAR)[1]
• in bioluminescent yeast bioreporters (BLYAS) assay[2]

Biochem/physiol Actions

Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation.[3] It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus.

Sedative; hypnotic; anticonvulsant; enhances GABAergic activity.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Dopamine and Norepinephrine Metabolism and GABAA Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H317,H351
• pcodes: P202 - P261 - P264 - P280 - P301 + P310 - P302 + P352
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges