P4247 Sigma-Aldrich Anti-Potassium Channel Kv1.3 (extracellular)−FITC antibody produced in rabbit is a rabbit polyclonal antibody, so it is a rabbit IgG-type antibody. Since there are no isotypes/subtypes for rabbit polyclonal IgG, the most suitable negative control would be a normal (i.e., non-immune) rabbit IgG that is conjugated to FITC. Unfortunately at this time, we do not offer an antibody such as this; however, we offer normal rabbit IgG that is either unconjugated (which could be conjugated with FITC at the end-user's facility), or conjugated to other fluorophores, e.g., 16-237 Sigma-Aldrich Normal Rabbit IgG, Alexa Fluor® 488 conjugate.
P4247
Anti-Potassium Channel Kv1.3 (extracellular)−FITC antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonim(y):
Anti-Kcna3, Anti-Voltage-gated Potassium Channel KV1.3
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Wybierz wielkość
P4247-50UL
3700,00 zł
3700,00 zł
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Informacje o tej pozycji
Conjugate:
FITC conjugate
Clone:
polyclonal
Application:
FACS, WB
Citations:
4
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Pozwól nam pomócbiological source
rabbit
conjugate
FITC conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat, human, mouse
technique(s)
flow cytometry: 0.5-5 μg/test using Jurkat T-cells, western blot: 1:200-1:500 using rat brain membranes
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KCNA3(3738)
mouse ... Kcna3(16491)
rat ... Kcna3(29731)
1 of 4
Ta pozycja | |||
|---|---|---|---|
| conjugate FITC conjugate | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| antibody form affinity isolated antibody | antibody form IgG fraction of antiserum | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
General description
The (K+) channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM (K+) channels based on the number of transmembrane domains. The voltage-gated Potassium or (Kv) channels belong to the 6 TM (K+) channel family and are expressed mainly in hematopoietic cells such as T and B lymphocytes, macrophages and natural killer cells. (Kv)1.3 facilitates cell proliferation and can also regulate the immune system. Genetic alterations in (Kv) 1.3 lead to epilepsy, episodic ataxia/myokymia, and episodic cardiac arrhythmia (the long QT syndrome). Anti-potassium channel (Kv) 1.3 (extracellular)−FITC antibody can be used for western blotting of rat brain membranes. Rabbit anti- potassium channel (Kv) 1.3 (extracellular) antibodies reacts specifically with rat and human (Kv) 1.3.
Immunogen
synthetic peptide corresponding to residues 211-224 of human KV1.3. Rat and mouse are 12/14 residues identical.
Application
Anti-potassium channel (Kv) 1.3 (extracellular)−FITC antibody can be used in immunoblotting and flow cytometry.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, 1% bovine serum albumin, 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Klasa składowania
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
R S Lewis et al.
Annual review of immunology, 13, 623-653 (1995-01-01)
Over the past decade, a variety of ion channels have been identified and characterized in lymphocytes by use of the patch-clamp technique. This review discusses biophysical and regulatory aspects of lymphocyte potassium and calcium channels with the aim of understanding
Ildiko Szabo et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(3), 965-978 (2015-09-24)
Pharmacological inhibition of the potassium channel Kv1.3 has been shown to selectively kill B cells from patients with chronic lymphocytic leukemia (B-CLL). Here we aimed to biophysically characterize and compare Kv1.3 channel activity in B cells isolated either from healthy
Gergely Toldi et al.
International immunology, 22(9), 769-774 (2010-07-06)
Cytokine production in activated T lymphocytes of the term neonate is reduced compared with adults. We aimed to characterize the calcium influx kinetics of activated T lymphocytes in the neonate and to test the functionality and expression of Kv1.3 and
George A Gutman et al.
Pharmacological reviews, 55(4), 583-586 (2003-12-06)
This summary article presents an overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels. The complete Compendium, including data tables for each
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