N6414

NN-DNJ

≥98% (HPLC)

• Wzór empiryczny (zapis Hilla): C₁₅H₃₁NO₄
• Numer CAS: 81117-35-3
• Masa cząsteczkowa: 289.41
• NACRES: NA.77
• PubChem Substance ID: 329818665
• UNSPSC Code: 12352200
• MDL number: MFCD00905846
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL
• storage temp.: −20°C
• SMILES string: CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
• InChI: 1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1
• InChI key: FTSCEGKYKXESFF-LXTVHRRPSA-N

Opis

Biochem/physiol Actions

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone.

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves