N4412
Anti-Neurabin I antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonim(y):
Anti-Neural-tissue Specific F-actin Binding Protein I, Anti-Protein Phosphatase 1 Regulatory Subunit 9A
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About This Item
Numer MDL:
Kod UNSPSC:
12352203
pochodzenie biologiczne
rabbit
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
masa cząsteczkowa
antigen 180 kDa
reaktywność gatunkowa
mouse, rat
metody
microarray: suitable
western blot: 0.5-1 μg/mL using a rat brain extract (S1 fraction)
western blot: 1-2 μg/mL using mouse brain (fraction S1).
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
mouse ... Ppp1r9a(243725)
rat ... Ppp1r9a(84685)
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Opis ogólny
Neurabin I is expressed in the central nervous system of rats.
Neurabin I or neural tissue-specific F-actin-binding protein is highly enriched in dendritic spines. It comprises the F-actin binding domain at the N-terminus, a single PDZ interacting-domain and a C-terminal coiled-coil domain. Neurabin I is localized in the synapse of mature neurons and the lamellipodia of the growth cone during neuronal development.
Specyficzność
Anti-Neurabin I specifically recognizes neurabin I (180 kDa).
Immunogen
synthetic peptide located near the N-terminus of rat neurabin I (amino acids 341-361). This sequence is highly conserved (80%) in mouse neurabin I and not found in neurabin II/spinophilin.
Zastosowanie
Anti-Neurabin I antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Działania biochem./fizjol.
Neurabin I has a role in the assembly of F-actin. It has been shown to be associated with stimulation of hepatocarcinogenesis in rats.
Neurabin I is essential for neurite formation and binds to several proteins including F-actin, protein phosphatase 1 (PP1), p70 S6 kinase (p70S6K) and TGN38. Neurabin I/PP1 complex has been suggested to play a role in actin cytoskeleton dynamics and also in the control of cell morphology in mammalian neurons. The interaction of neurabin I with the trans-Golgi network membrane protein (TGN38) enables a link between TGN38-containing membranes and the actin cytoskeleton. Neurabin′s presence in fetal tissue may mediate early development, through regulation of actin cytoskeleton dynamics in the differentiation of skeletal muscle cells.
Opis wartości docelowych
Neurabin I (Neural-tissue specific F-actin bindingprotein I, PP1BP175, p180, also termed Proteinphosphatase 1 regulatory subunit 9A, PPP1R9A, 180kDa), belongs to a family of F-actin-binding proteins, including neurabin II/spinophilin, which are high
Postać fizyczna
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Przechowywanie i stabilność
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Opis
Cennik
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
nwg
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Crystal G Pontrello et al.
The open neuroscience journal, 3, 67-86 (2009-01-01)
Dendritic spines are actin-rich structures that accommodate the postsynaptic sites of most excitatory synapses in the brain. Although dendritic spines form and mature as synaptic connections develop, they remain plastic even in the adult brain, where they can rapidly grow
Anna Kakehashi et al.
Toxicological sciences : an official journal of the Society of Toxicology, 119(1), 61-72 (2010-10-12)
In the present study, protein lysates from microdissected glutathione S-transferase placental-form-positive (GST-P(+)) foci and hepatocellular carcinomas from livers of rats treated with N-diethylnitrosamine followed by phenobarbital at doses of 0 and 500 ppm in the diet for 10 and 33
Genomic imprinting of PPP1R9A encoding neurabin I in skeletal muscle and extra-embryonic tissues.
K Nakabayashi et al.
Journal of medical genetics, 41(8), 601-608 (2004-08-03)
D J Stephens et al.
The Journal of biological chemistry, 274(42), 30080-30086 (1999-10-09)
TGN38 is a type I integral membrane protein that constitutively cycles between the trans-Golgi network (TGN) and plasma membrane. The cytosolic domain of TGN38 interacts with AP2 clathrin adaptor complexes via the tyrosine-containing motif (-SDYQRL-) to direct internalization from the
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