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MAK257

Tyrosinase Inhibitor Screening Kit (Colorimetric)

sufficient for 100 colorimetric tests

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Informacje o tej pozycji

NACRES:
NA.25
UNSPSC Code:
12161503

application(s)

cosmetics
food and beverages

detection method

colorimetric

relevant disease(s)

dermatological diseases

storage temp.

−20°C

General description

Tyrosinase or polyphenol oxidase (EC 1.14.18.1), is an oxidoreductase that participates in the biosynthesis of melanin, a ubiquitous biological pigment found in hair, eyes, skin, etc. Inhibition of tyrosinase has been a long-time target in the skin health research, cosmetics and agricultural industries because of its role in browning reactions in skin pigmentation and during fruit harvesting and handling. Skin whitening and bleaching products utilize natural or synthetic tyrosinase inhibitors in order to lighten the skin color. Polyphenols, benzaldehyde derivatives, long-chain lipids, steroids, and natural compounds have been used as tyrosinase inhibitors.
Deficiency in tyrosinase causes albino, a condition in which the melanocytes are not able to produce melanin. This increases the risk of skin cancer.

Application

Suitable for screening/studying/characterizing tyrosinase inhibitors.

Biochem/physiol Actions

Tyrosinase catalyzes the oxidation of tyrosine, producing a chromophore that can be detected at 510 nm. In the presence of kojic acid, a reversible inhibitor of tyrosinase, the rate of oxidation of the substrate is decreased. The kit provides a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of tyrosinase inhibitors. The assay is also adaptable to a 384 well format.

Features and Benefits

Compatible with high-throughput handling systems.
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pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

hcodes

H318,H334

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1

Klasa składowania

10 - Combustible liquids

flash_point_f

188.6 °F

flash_point_c

87 °C

    • Wybierz jedną z najnowszych wersji:

    Certyfikaty analizy (CoA)

    Lot/Batch Number
    8H11K05750
    8K21K05750
    8B28K05750
    SLBW0752
    SLCD0856

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    Questions

    1–3 of 3 Questions  

    1. How can I determine the shelf life / expiration / retest date of this product?

      1 answer

      1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
        For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
        For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
        For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

        Helpful?

    2. How is shipping temperature determined? And how is it related to the product storage temperature?

      1 answer

      1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

        Helpful?

    3. How many analisys this kit provide?

      1 answer

      1. This kit is sufficient to perform 100 tests in a 96-well plate format, including standards and duplicates. Please see the link below to review the product data sheet: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/125/489/mak257bul.pdf

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