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MAK068

Sigma-Aldrich

MPO Colorimetric Activity Assay Kit

sufficient for 100 colorimetric tests

Synonim(y):

Myeloperoxidase Colorimetric Activity Assay Kit

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About This Item

Kod UNSPSC:
12161503
NACRES:
NA.84
Informacje o cenach i dostępności nie są obecnie dostępne.

zastosowanie

sufficient for 100 colorimetric tests

metoda wykrywania

colorimetric

powiązane choroby

cancer; cardiovascular diseases; hematological disorder

temp. przechowywania

−20°C

informacje o genach

human ... MPO(4353)
mouse ... MPO(17523)
rat ... MPO(303413)

Opis ogólny

Myeloperoxidase (MPO) is a heme-containing enzyme that catalyzes the hydrogen peroxidase-mediated oxidation of halide ions to hypochlorous acid. MPO is a lysosomal protein, highly expressed in neutrophils, that plays a role in the antimicrobial actions that occur as a result of neutrophil stimulation. The actions of MPO may also contribute to the initiation and pathogenesis of cardiovascular disease.

Zastosowanie

MPO Colorimetric Activity Assay Kit has been used to determine the activity of myeloperoxidase in samples.[1][2][3]

Cechy i korzyści

Compatible with high-throughput handling systems.

Przydatność

Suitable for the measurement of myeloperoxidase (MPO) in biological samples such as tissue, cells, serum and white blood cells

Zasada

In this assay, MPO catalyzes the formation of hypochlorous acid, which reacts with taurine to form taurine chloroamine. Taurine chloroamine reacts with the chromophore TNB, resulting in the formation of the colorless product DTNB. One unit of MPO activity is defined as the amount of enzyme that hydrolyzes the substrate and generates taurine chloramine to consume 1.0 μmole of TNB per minute at 25 °C.
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Piktogramy

Health hazard
GHS08

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H315,H319,H334

Zwroty wskazujące środki ostrożności

P261 - P264 - P280 - P284 - P302 + P352 - P305 + P351 + P338

Klasyfikacja zagrożeń

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2

Kod klasy składowania

10 - Combustible liquids

Temperatura zapłonu (°F)

188.6 °F

Temperatura zapłonu (°C)

87 °C

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
8F23K07440
7L08K07440
7G02K07440
7B17K07440
6L24K07440

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Wyszukaj dokument COA

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Odwiedź Bibliotekę dokumentów

Yannan Liu et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(5), G550-G563 (2014-07-19)
Understanding the regulation of death pathways, necrosis and apoptosis, in pancreatitis is important for developing therapies directed to the molecular pathogenesis of the disease. Protein kinase Cε (PKCε) has been previously shown to regulate inflammatory responses and zymogen activation in
Plasma nitration of high-density and low-density lipoproteins in chronic kidney disease patients receiving kidney transplants.
Bakillah A, et al.
Mediators of Inflammation, 2015 (2015)
Ruisong Pei et al.
Molecular nutrition & food research, 63(5), e1800985-e1800985 (2018-12-07)
Increased fruit consumption is associated with reduced risk of colitis. It has been investigated whether the anti-colitic effects of the polyphenol-rich aronia berry (Aronia mitschurinii 'Viking') are mediated through Th17 and Treg. Colitis is induced in recombinase activating gene-1 deficient
Ivan Luzardo-Ocampo et al.
Food research international (Ottawa, Ont.), 132, 109097-109097 (2020-04-26)
Ulcerative colitis (UC) is a condition that has been rising in the number of cases around the world. Food products made from natural ingredients such as corn and common bean might serve as alternatives for the treatment of UC. This
Lei Tu et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(4), G624-G634 (2020-02-19)
Sacral nerve stimulation (SNS) was reported to improve 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. The aim of this study was to investigate whether the SNS anti-inflammatory effect is mediated via the local sacral splanchnic nerve or the spinal afferent-vagal efferent-colon
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Does hemoglobin interfere with the MAK068 MPO Colorimetric Activity Assay Kit?

    1 answer

    1. Hemoglobin is not known to cause interference. The sample background should account for any background signal other than the intended signal.

      Helpful?

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