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MAK068

MPO Colorimetric Activity Assay Kit

sufficient for 100 colorimetric tests

Synonim(y):

Myeloperoxidase Colorimetric Activity Assay Kit

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Informacje o tej pozycji

NACRES:
NA.84
UNSPSC Code:
12161503

usage

sufficient for 100 colorimetric tests

detection method

colorimetric

relevant disease(s)

cancer; cardiovascular diseases; hematological disorder

storage temp.

−20°C

Gene Information

human ... MPO(4353)
mouse ... MPO(17523)
rat ... MPO(303413)

General description

Myeloperoxidase (MPO) is a heme-containing enzyme that catalyzes the hydrogen peroxidase-mediated oxidation of halide ions to hypochlorous acid. MPO is a lysosomal protein, highly expressed in neutrophils, that plays a role in the antimicrobial actions that occur as a result of neutrophil stimulation. The actions of MPO may also contribute to the initiation and pathogenesis of cardiovascular disease.

Application

MPO Colorimetric Activity Assay Kit has been used to determine the activity of myeloperoxidase in samples.
Suitable for the measurement of myeloperoxidase (MPO) in biological samples such as tissue, cells, serum and white blood cells

Biochem/physiol Actions

In this assay, MPO catalyzes the formation of hypochlorous acid, which reacts with taurine to form taurine chloroamine. Taurine chloroamine reacts with the chromophore TNB, resulting in the formation of the colorless product DTNB. One unit of MPO activity is defined as the amount of enzyme that hydrolyzes the substrate and generates taurine chloramine to consume 1.0 μmole of TNB per minute at 25 °C.

Features and Benefits

Compatible with high-throughput handling systems.
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pictograms

Health hazard
GHS08

signalword

Danger

Klasa składowania

10 - Combustible liquids

flash_point_f

188.6 °F

flash_point_c

87 °C

wgk

WGK 2

Hazard Classifications

ED ENV 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Does hemoglobin interfere with the MAK068 MPO Colorimetric Activity Assay Kit?

    1 answer

    1. Hemoglobin is not known to cause interference. The sample background should account for any background signal other than the intended signal.

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