L0906
L-α-Lysophosphatidylcholine from Glycine max (soybean)
≥99%, lyophilized powder
Synonim(y):
1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
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About This Item
Polecane produkty
pochodzenie biologiczne
soybean
Poziom jakości
opis
zwitterionic
Próba
≥99%
Postać
lyophilized powder
grupa funkcyjna
phospholipid
typ lipidu
phosphoglycerides
Warunki transportu
ambient
temp. przechowywania
−20°C
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Działania biochem./fizjol.
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.
Opakowanie
Packaged under Argon.
Uwaga dotycząca przygotowania
Prepared by the action of phospholipase A on soybean L-α-phosphatidylcholine (P 6263).
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
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Improving vaccine immunogenicity by developing new adjuvant formulations has long been a goal of vaccinologists. It has previously been shown that a natural mix of lysophosphatidylcholine (LPC) from chicken eggs promotes mature dendritic cell (DC) generation in vitro and primes
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Cellular and molecular life sciences : CMLS, 75(24), 4599-4617 (2018-09-20)
Lysophosphatidylcholine (LysoPC) has been shown to induce the expression of inflammatory proteins, including cyclooxygenase-2 (COX-2) and interleukin-6 (IL-6), associated with cardiac fibrosis. Here, we demonstrated that LysoPC-induced COX-2 and IL-6 expression was inhibited by silencing NADPH oxidase 1, 2, 4
Oliver Murch et al.
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1. Lysophosphatidylcholine (LPC) modulates the inflammatory response and reduces mortality in animal models of sepsis. Here, we investigate the effects of LPC from synthetic (sLPC) and natural, soy bean derived LPC, (nLPC) sources on the organ injury/dysfunction caused by systemic
Hui-Ching Tseng et al.
Journal of lipid research, 60(9), 1573-1589 (2019-08-01)
Lysophosphatidylcholine (LPC) may accumulate in the heart to cause fibrotic events, which is mediated through fibroblast activation and collagen accumulation. Here, we evaluated the mechanisms underlying LPC-mediated collagen induction via mitochondrial events in human cardiac fibroblasts (HCFs), coupling application of
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