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K3268

PAK7, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonim(y):

KIAA1264, MGC26232, PAK5

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Gabaryty przesyłkiSKUDostępnośćCena netto
10 μg
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
1860,00 zł

Informacje o tej pozycji

NACRES:
NA.32
UNSPSC Code:
51111800
Specific activity:
47-63 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells

1860,00 zł

Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

47-63 nmol/min·mg

mol wt

~130 kDa

UniProt accession no.

Q9P286

relevant disease(s)

cancer

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PAK7(57144)

Biochem/physiol Actions

PAK7 (p21 protein (Cdc42/Rac)-activated kinase 7) belongs to the group-2 PAKs and can activate JNK (Jun N-terminus kinase).[1][2] It contain an amino-terminal CDC42 (cell division cycle 42)/RAC (AKT1, v-akt murine thymoma viral oncogene homolog 1) interactive domain and a carboxyl terminal kinase domain.[3] It plays an important role in outgrowth of neuron cells and synaptic vesicle trafficking. In mice, absence of PAK7 and PAK6 causes learning and locomotion defects. It is mainly expressed in brain. However, it is also considered as an oncogene because of its expression in colorectal, esophageal and gastric cancers.[4]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
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Ta pozycja
P7373M0699SRP5056
PAK7, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

K3268

PAK7, active, GST tagged human

PAK7 Active human ≥75% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

Sigma-Aldrich

P7373

PAK7 Active human

MSK1, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

M0699

MSK1, active, GST tagged human

PAK6, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5056

PAK6, active, GST tagged human

specific activity

47-63 nmol/min·mg

specific activity

10 units/mg protein (Bradford)

specific activity

75-103 nmol/min·mg

specific activity

116-158 nmol/min·mg

assay

≥70% (SDS-PAGE)

assay

≥75% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

Gene Information

human ... PAK7(57144)

Gene Information

human ... PAK7(57144)

Gene Information

human ... RPS6KA5(9252)

Gene Information

human ... PAK6(56924)

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in E. coli

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

mol wt

~130 kDa

mol wt

protein apparent mol wt ~116 kDa by SDS-PAGE

mol wt

~120 kDa

mol wt

~110 kDa

Klasa składowania

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Powiązane treści

Data Sheet - K3268

Instructions

Shun He et al.
PloS one, 9(12), e113989-e113989 (2014-12-02)
Aurora-A overexpression is common in various types of cancers and has been shown to be involved in tumorigenesis through different signaling pathways, yet how the deregulation affects cancer therapeutics remains elusive. Here we showed that overexpression of Aurora-A rendered esophageal
Akhilesh Pandey et al.
Oncogene, 21(24), 3939-3948 (2002-05-29)
The p21-activated kinase (PAK) family of protein kinases has recently attracted considerable attention as an effector of Rho family of small G proteins and as an upstream regulator of MAPK signalling pathways during cellular events such as re-arrangement of the
Kun Han et al.
Cell biology international, 38(12), 1394-1402 (2014-07-24)
p21-activated kinase 7 (PAK7), also named as PAK5, is a member of Rac/Cdc42-associated Ser/Thr protein kinases. It is overexpressed in some types of cancer such as colorectal and pancreatic cancers. However, the expression status and biological function of PAK7 in
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Numer pozycji handlu globalnego

SKUNUMER GTIN
K3268-10UG04061837755965

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