K1751

Ketoprofen

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

• Synonim(y): 2-(3-Benzoylphenyl)propionic acid
• Wzór empiryczny (zapis Hilla): C₁₆H₁₄O₃
• Numer CAS: 22071-15-4
• Masa cząsteczkowa: 254.28
• NACRES: NA.77
• PubChem Substance ID: 57654315
• UNSPSC Code: 12352200
• EC Number: 244-759-8
• MDL number: MFCD00055790
• Assay: ≥98% (TLC)
• Form: powder

Właściwości

• Nazwa produktu: Ketoprofen, ≥98% (TLC)
• biological source: synthetic
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: ethanol: 50 mg/mL, clear, colorless to yellow
• originator: Bayer
• SMILES string: CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2
• InChI: 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
• InChI key: DKYWVDODHFEZIM-UHFFFAOYSA-N
• Gene Information: human ... ALB(213), IL8RA(3577), PTGS1(5742), PTGS2(5743)

Opis

General description

Ketoprofen belongs to the class of 2-arylpropionic acid.

Application

Ketoprofen has been used:

• as sample to analyse the effects of long storage period by chromatographic and microscopic techniques
• as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation
• in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin

Biochem/physiol Actions

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.

Non-steroidal anti-inflammatory compound that is selective for COX-1.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301,H315,H319,H400
• pcodes: P264 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges