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K0889

Anti-Kinesin 5A antibody produced in rabbit

Name: Anti-Kinesin 5A antibody produced in rabbit
Brand: SIGMA
Price: 2550 PLN

affinity isolated antibody, buffered aqueous solution

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Gabaryty przesyłki	SKU	Dostępność	Cena netto
100 μg		Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności	2550,00 zł

Informacje o tej pozycji

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD07370384

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

2550,00 zł

Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności

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Pozwól nam pomóc

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

bovine, human, mouse

technique(s)

western blot: 0.4 μg/mL using mouse neuronal cell lysate and human retinal extracts

UniProt accession no.

Q12840

Powiązane kategorie

Antibodies - Primary, Secondary & Recombinant Monoclonal

Primary Antibodies

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Ta pozycja	K3513	SAB3500282	HPA004469
Sigma-Aldrich K0889 Anti-Kinesin 5A antibody produced in rabbit	$Anti-KIF3A antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich K3513 Anti-KIF3A antibody produced in rabbit	Sigma-Aldrich SAB3500282 Anti-KIF5 antibody produced in rabbit	Sigma-Aldrich HPA004469 Anti-KIF5A antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
technique(s) western blot: 0.4 μg/mL using mouse neuronal cell lysate and human retinal extracts	technique(s) immunohistochemistry: suitable using suitable for IHC on rat brain perfused with 4% paraformaldehyde, microarray: suitable, western blot: 1:2,000 using rat brain homogenate and whole cell extract of rat pheochromocytoma PC12 cell line.	technique(s) immunocytochemistry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable	technique(s) immunoblotting: 0.04-0.4 μg/mL, immunohistochemistry: 1:50-1:200
Gene Information human ... KIF5A(3798) mouse ... Kif5a(16572)	Gene Information human ... KIF3A(11127) mouse ... Kif3a(16568) rat ... Kif3a(84392)	Gene Information human ... KIF5A(3798)	Gene Information human ... KIF5A(3798)

General description

The gene KIF5A (kinesin family member 5A) is mapped to human chromosome 12. The encoded kinesin is expressed in all neurons, and present in neuronal cytoplasm, which includes the cell body, dendrites, and axon.

Immunogen

synthetic peptide corresponding to amino acid residues 1007-1027 from mouse kinesin 5A.

Application

Anti-Kinesin 5A antibody produced in rabbit has been used in immunofluorescence and immunohistochemistry[1].

Biochem/physiol Actions

The gene KIF5A (kinesin family member 5A) encodes a kinesin heavy chain that may be involved in the microtubule-dependent slow axonal transport of neurofilament proteins.
Mutations in this gene have been associated with hereditary spastic paraplegia.

Physical form

Solution in phosphate buffered saline containing 1 mg/mL BSA and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Klasa składowania

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A.

Xia CH

The Journal of Cell Biology, 161, 55-66 (2003)

A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10).

Evan Reid et al.

American journal of human genetics, 71(5), 1189-1194 (2002-10-02)

We have identified a missense mutation in the motor domain of the neuronal kinesin heavy chain gene KIF5A, in a family with hereditary spastic paraplegia. The mutation occurs in the family in which the SPG10 locus was originally identified, at

Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport.

Ping Shi et al.

Biochimica et biophysica acta, 1802(9), 707-716 (2010-06-01)

Transport of material and signals between extensive neuronal processes and the cell body is essential to neuronal physiology and survival. Slowing of axonal transport has been shown to occur before the onset of symptoms in amyotrophic lateral sclerosis (ALS). We

Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis.

Ingo Spitzbarth et al.

Brain and behavior, 6(7), e00472-e00472 (2016-06-02)

CDV-DL (Canine distemper virus-induced demyelinating leukoencephalitis) represents a spontaneously occurring animal model for demyelinating disorders. Axonopathy represents a key pathomechanism in this disease; however, its underlying pathogenesis has not been addressed in detail so far. This study aimed at the

Neurotrophic effects of GM1 ganglioside, NGF, and FGF2 on canine dorsal root ganglia neurons in vitro.

S Schwarz et al.

Scientific reports, 10(1), 5380-5380 (2020-03-28)

Dogs share many chronic morbidities with humans and thus represent a powerful model for translational research. In comparison to rodents, the canine ganglioside metabolism more closely resembles the human one. Gangliosides are components of the cell plasma membrane playing a

Numer pozycji handlu globalnego

SKU	NUMER GTIN
K0889-100UG	04061838071446

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