I8779
Insulin-like Growth Factor-I from mouse
IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonim(y):
IGF-I
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About This Item
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
rekombinowane
expressed in E. coli
Próba
≥98% (SDS-PAGE and HPLC)
Postać
lyophilized powder
jakość
endotoxin tested
masa cząsteczkowa
predicted mol wt ~7.6 kDa
opakowanie
glass bottle of 50 μg (in glass insert)
metody
cell culture | mammalian: suitable
zanieczyszczenia
<0.1 ng/mg (LAL test)
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
human ... IGF1(3479)
mouse ... Igf1(16000)
Opis ogólny
Insulin-like growth factor I (IGF-I) belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules. IGF-I is also known as somatomedin. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells.
Zastosowanie
Insulin-like Growth Factor-I from mouse has been used:
- for the preparation of growth factor cocktail
- as a media supplement for mouse embryonic fibroblasts culture
- as a media supplement to serve as a positive control to investigate
- the effects of Angelica sinensis on myotubes
Działania biochem./fizjol.
Insulin-like growth factor I (IGF-I) plays critical roles in cellular energy metabolism and in growth and development, especially prenatal growth.
IGF-I is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
IGF-I is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
Potent mitogenic growth factor that mediates the growth-promoting activities of growth hormone postnatally. Mouse and human IGF-I share 97% sequence identity.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Komentarz do analizy
The biological activty is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line, MCF-7.
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produkt powiązany
Numer produktu
Opis
Cennik
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
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Produkty
Insulin-like Growth Factors (IGF)
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