Przejdź do zawartości
Merck
Wszystkie zdjęcia(1)

Dokumenty

I5273

Sigma-Aldrich

Interleukin-5 human

recombinant, expressed in baculovirus infected Sf21 cells, ≥97% (SDS-PAGE), lyophilized powder, suitable for cell culture

Synonim(y):

IL-5

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wszystkie zdjęcia(1)

About This Item

Numer MDL:
MFCD00163946
Kod UNSPSC:
12352202
NACRES:
NA.32

pochodzenie biologiczne

human

Poziom jakości

200

rekombinowane

expressed in baculovirus infected Sf21 cells

Próba

≥97% (SDS-PAGE)

Postać

lyophilized powder

siła działania

0.1-0.5 ng/mL EC50

masa cząsteczkowa

32-34 kDa

opakowanie

pkg of 5 μg

stężenie

0.5-10 ng/mL

metody

cell culture | mammalian: suitable

zanieczyszczenia

endotoxin, tested

numer dostępu UniProt

P05113

temp. przechowywania

−20°C

informacje o genach

human ... IL5(3567)

Powiązane kategorie

Działania biochem./fizjol.

IL-5 (interleukin-5) is a maturation and differentiation factor for eosinophils. Thus, it is associated with allergy and related disorders. IL-5 association with its receptor causes activation of MEK/ERK (mitogen activated protein kinase kinase/extracellular-regulated kinase), p38 MAPK (mitogen activated protein kinase) and JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathways.
Interleukin-5 is a product of activated T lymphocytes and exhibits activity on eosinophils, B cells and thymocytes. Synonyms or biological activities attributed to IL-5 include: EDF (eosinophil differentiating factor), BCGF-II (B cell growth factor-II), TRF (T cell replacing factor), IgA-EF (IgA enhancing factor) and EO-CSF (eosinophil colony stimulating factor). Natural IL-5 is a 45-50 kDa dimeric glycoprotein, although glycosylation is not required for activity. Human and mouse IL-5 exhibit homology at the nucleotide and amino acid levels and show species cross-reactivity.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.1 mg bovine serum albumin.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Angela Silveira et al.
Atherosclerosis, 239(1), 125-130 (2015-01-15)
Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma
Takehito Kobayashi et al.
Allergology international : official journal of the Japanese Society of Allergology, 64 Suppl, S30-S36 (2015-09-08)
Eosinophils recognize various stimuli, such as cytokines, chemokines, immunoglobulins, complement, and external pathogens, resulting in their accumulation in mucosal tissues and the progression of inflammation. Eosinophils are also involved in innate Th2-type immune responses mediated through endogenous danger signals, including
Mandy E Burnham et al.
PloS one, 9(8), e103122-e103122 (2014-08-15)
Eosinophils function contributes to human allergic and autoimmune diseases, many of which currently lack curative treatment. Development of more effective treatments for eosinophil-related diseases requires expanded understanding of eosinophil signaling and biology. Cell signaling requires integration of extracellular signals with
Ma Paz Zafra et al.
International journal of molecular sciences, 16(3), 5434-5451 (2015-03-13)
Eosinophils are one of the key inflammatory cells in asthma. Eosinophils can exert a wide variety of actions through expression and secretion of multiple molecules. Previously, we have demonstrated that eosinophils purified from peripheral blood from asthma patients express high

Produkty

Interleukin Family (IL)

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej