This product is offered in a powdered format. Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
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I5159
Imiquimod
≥98% (HPLC), solid, caspase 3 activator
Synonim(y):
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
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| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
200 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 975,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C14H16N4
Numer CAS:
Masa cząsteczkowa:
240.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
975,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Imiquimod, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
solubility
H2O: <2 mg/mL, DMSO: 4 mg/mL (warming to 60 °C for 15 minutes)
SMILES string
CC(C)Cn1cnc2c(N)nc3ccccc3c12
InChI
1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChI key
DOUYETYNHWVLEO-UHFFFAOYSA-N
Gene Information
human ... TLR7(51284)
General description
Imiquimod is a toll-like receptor (TLR)-7/8 agonist.
Application
Imiquimod has been used as TLR7 agonist for TLR7 agonist enhancement studies. It has also been used as an NLR family, pyrin domain containing 3 (NLRP3) stimulant to treat NLRP3-FL-Btn and FLAG-ASC-FL.
Biochem/physiol Actions
Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo in basal cell carcinoma. Its anti-tumor activity is related to the induction of apoptosis. Imiquimod has anti-angiogenic, anti-inflammatory, anti-viral activities. Imiquimod also acts as an immune response modulator inducing the secretion of various cytokines and chemokines.
Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo and acts as an immunomodulator with anti-viral and anti-inflammatory perties.
Imiquimod helps to induce the innate cutaneous immunity and the cellular arm of the adaptive immune response.
Features and Benefits
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Ta pozycja | |||
|---|---|---|---|
| description ≥98% (HPLC), solid | description United States Pharmacopeia (USP) Reference Standard | description ≥98% (HPLC) | description Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 500 mg |
| form solid | form - | form powder | form solid |
| assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) | assay - |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 300 |
| solubility H2O: <2 mg/mL, DMSO: 4 mg/mL (warming to 60 °C for 15 minutes) | solubility - | solubility DMSO: 10 mg/mL, clear | solubility - |
| Gene Information human ... TLR7(51284) | Gene Information human ... TLR7(51284) | Gene Information - | Gene Information - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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