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Merck

I2644

Sigma-Aldrich

Interleukin-2 human

IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonim(y):

IL-2, hIL-2, Interleukin-2, T-cell growth factor

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About This Item

Numer MDL:
Kod UNSPSC:
12352202
NACRES:
NA.77

pochodzenie biologiczne

human

Poziom jakości

rekombinowane

expressed in E. coli

Postać

lyophilized powder

siła działania

≤700 EC50

jakość

endotoxin tested

masa cząsteczkowa

15.5 kDa

opakowanie

pkg of 5X10 μg
pkg of 10 μg

metody

cell culture | mammalian: suitable

zanieczyszczenia

≤1 EU/μg

numer dostępu UniProt

temp. przechowywania

−20°C

informacje o genach

human ... IL2(3558)

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Opis ogólny

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

Zastosowanie

Interleukin-2 human has been used:
  • in the stimulation of natural killer cells
  • to study its ability to stimulate lymphocyte growth and prevent apoptosis
  • as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus

Działania biochem./fizjol.

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. It mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Postać fizyczna

Lyophilized, 0.2 μm filtered, no additives.

Komentarz do analizy

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype
Pridgeon C, et al.
Rheumatology (Basel), 42(7), 870-878 (2003)
Interleukin 2, 37-37 (2012)
Stefania Braidotti et al.
Frontiers in bioscience (Landmark edition), 27(2), 39-39 (2022-03-01)
The T-cell engager antibody blinatumomab (BlincytoT⁢M) represents a promising rescue therapy for relapsed/refractory CD19+ acute lymphoblastic leukemia (B-ALL), although ~20-30% of patients still do not respond to treatment. Blinatumomab creates a tight synapsis between CD3+ T-lymphocytes and leukemic CD19+ B-cells
Association of- 330 interleukin-2 gene polymorphism with oral cancer
Singh PK, et al.
The Indian Journal of Medical Research, 146(6), 730-730 (2017)
Association of Interleukin-2-330T/G and Interleukin-10-1082A/G Genetic Polymorphisms with B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians
Rahman HAA, et al.
Turkish journal of haematology : official journal of Turkish Society of Haematology, 35(2), 99-99 (2018)

Produkty

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

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