H9146

13(S)-Hydroxyoctadeca-9Z,11E-dienoic acid

90-100 μg/mL in ethanol, ≥98%

• Synonim(y): 13(S)-HODE
• Wzór empiryczny (zapis Hilla): C₁₈H₃₂O₃
• Numer CAS: 29623-28-7
• Masa cząsteczkowa: 296.44
• NACRES: NA.77
• PubChem Substance ID: 24895844
• UNSPSC Code: 12352200
• EC Number: 200-578-6
• MDL number: MFCD00065833

Właściwości

• Quality Segment: 100
• assay: ≥98%
• concentration: 90-100 μg/mL in ethanol
• storage temp.: −20°C
• SMILES string: CCCCC[C@H](O)\C=C\C=C/CCCCCCCC(O)=O
• InChI: 1S/C18H32O3/c1-2-3-11-14-17(19)15-12-9-7-5-4-6-8-10-13-16-18(20)21/h7,9,12,15,17,19H,2-6,8,10-11,13-14,16H2,1H3,(H,20,21)/b9-7-,15-12+/t17-/m0/s1
• InChI key: HNICUWMFWZBIFP-IRQZEAMPSA-N

Opis

Biochem/physiol Actions

Expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13(S)-HODE, are decreased in human colorectal and esophageal cancers. Certain non-steroidal anti-inflammatory drugs (NSAIDs) can induce apoptosis in human colon cancer cells by increased expression of 15-LOX-1, which down-regulates PPAR-delta through 13-HODE.

PPARγ agonist

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Packaged under Argon.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS07
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H225,H319
• Ostrzeżenia: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Klasa składowania: 3 - Flammable liquids
• Co się dzieje?: WGK 1
• Temperatura zapłonu (°F): 57.2 °F
• Temperatura zapłonu (°C): 14 °C