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H7789

Anti-acetyl-Histone H1.4 (Ac-Lys²⁶) antibody produced in rabbit

Name: Anti-acetyl-Histone H1.4 (Ac-Lys<SUP>26</SUP>) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonim(y):

Anti-H1 Histone family, member 4, Anti-H1.4K26ac, Anti-H1K26ac, Anti-H1e, Anti-Histone 1, Anti-Histone H1b

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Informacje o tej pozycji

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD09753843

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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Właściwości

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~35 kDa

species reactivity

human

technique(s)

western blot: 0.5-1 μg/mL using acid-extracted fraction of HL60 cells

UniProt accession no.

P10412

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

acetylation (Lys26)

Gene Information

human ... HIST1H1E(3008)

Opis

General description

In mammalian cells, four histone H1 variants (H1.2 to H1.5) are present in all somatic cells, and a fifth (H1.1) is restricted to thymus, testis, and spleen and possibly lymphocytic and neuronal cells. Histone H1.4 is di-methylated or acetylated at Lys26. Lys26 is located within the flexible N-terminal domain of H1.4, just preceding the globular domain.

Immunogen

synthetic acetylated peptide corresponding to amino acids 22-33 (Ac-Lys²⁶) of human histone H1.4.

Application

Anti-acetyl-Histone H1.4 (Ac-Lys26) antibody produced in rabbit is suitable for western blot at a concentration of 0.5-1μg/mL using acid-extracted fraction of HL60 cells.

Anti-acetyl-Histone H1.4 (Ac-Lys²⁶) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

H1.4 at lysine residue 26 represses transcription. Linker histone H1 binds to DNA between nucleosomal core particles and is involved in establishing and maintaining higher order chromatin structures. Histone modifications are thought to play an important role in cancer and disease.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Ta pozycja	H7665	SAB4200485	M4819
Sigma-Aldrich H7789 Anti-acetyl-Histone H1.4 (Ac-Lys²⁶) antibody produced in rabbit	Sigma-Aldrich H7665 Anti-Histone H1.4 antibody produced in rabbit	Sigma-Aldrich SAB4200485 Anti-acetyl-Histone H3 (Ac-Lys²⁷) antibody produced in rabbit	Sigma-Aldrich M4819 Anti-methyl-Histone H3 (Me-Lys⁴) antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
technique(s) western blot: 0.5-1 μg/mL using acid-extracted fraction of HL60 cells	technique(s) western blot: 1-2 μg/mL using acid-extracted fraction of HL60 cells	technique(s) immunohistochemistry: 10-20 μg/mL, indirect immunofluorescence: 2.5-5.0 μg/mL using HeLa cells, western blot: 1-2 μg/mL using extracts of NIH3T3 cells	technique(s) western blot: 0.5-1 μg/mL using whole cell extract of human HeLa cells, human Jurkat cells, or mouse NIH3T3 cells
Gene Information human ... HIST1H1E(3008)	Gene Information human ... HIST1H1E(3008)	Gene Information human ... HIST3H3(8290)	Gene Information human ... H3F3A(3020), H3F3B(3021), HIST1H3A(8350), HIST1H3B(8358), HIST1H3C(8352), HIST1H3D(8351), HIST1H3E(8353), HIST1H3F(8968), HIST1H3G(8355), HIST1H3H(8357), HIST1H3I(8354), HIST1H3J(8356), HIST2H3A(333932), HIST2H3C(126961), HIST3H3(8290) mouse ... H3f3a(15078), H3f3b(15081), Hist1h3a(360198), Hist1h3b(319150), Hist1h3c(319148), Hist1h3d(319149), Hist1h3e(319151), Hist1h3f(260423), Hist1h3g(97908), Hist1h3h(319152), Hist1h3i(319153), Hist2h3b(319154), Hist2h3c1(15077), Hist2h3c2(97114) rat ... H3f3b(117056)
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution

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Klasa składowania

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c