H7125

Histamine

≥97% (TLC), powder, H₁ and H₂ histamine receptor agonist

• Synonim(y): 2-(4-Imidazolyl)ethylamine
• Wzór empiryczny (zapis Hilla): C₅H₉N₃
• Numer CAS: 51-45-6
• Masa cząsteczkowa: 111.15
• NACRES: NA.77
• PubChem Substance ID: 24895783
• eCl@ss: 32160406
• UNSPSC Code: 12352116
• EC Number: 200-100-6
• MDL number: MFCD00005210
• Beilstein/REAXYS Number: 2012
• Assay: ≥97.0%

Właściwości

• Nazwa produktu: Histamine, ≥97.0%
• Quality Segment: 200
• assay: ≥97.0%
• bp: 167 °C/0.8 mmHg (lit.)
• mp: 83-84 °C (lit.)
• storage temp.: −20°C
• SMILES string: NCCc1c[nH]cn1
• InChI: 1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
• InChI key: NTYJJOPFIAHURM-UHFFFAOYSA-N
• Gene Information: human ... CA1(759), CA2(760), HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340) ; rat ... Hrh1(24448), Hrh3(85268)

Opis

General description

Histamine is a neurotransmitter produced by neurons of the posterior hypothalamus. In the brain, histamine is predominantly present in the gray matter.

Application

Histamine has been used:

• to stimulate regulated cellular secretion
• in reaction mixture to activate blood for assaying thrombin (factor iia) activity by fluorimetry
• to fill the luminal side of the chamber to investigate its effects on the TJ-related barrier and the expression of TJ (tight junction) markers in the vocal fold epithelium

Biochem/physiol Actions

Histamine participates in innate and acquired immune response, mediating allergy and inflammation. It helps in intestinal muscle contraction. During anaphylactic shock histamine causes bronchial constriction. Histamine is also involved in gastric acid secretion, epithelial and endothelial barrier control.

Endogenous H₁ and H₂ histamine receptor agonist; H₁ activation mobilizes Ca²⁺; H₂ activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator.

Endogenous H₁ and H₂ histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301,H315,H317,H319,H334,H335
• Ostrzeżenia: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Faceshields, Gloves