H0266

Hemoglobin A₂, Ferrous Stabilized human

lyophilized powder

• Numer CAS: 9034-53-1
• UNSPSC Code: 12352202
• eCl@ss: 42030116
• EC Number: 232-897-1
• NACRES: NA.61
• MDL number: MFCD00131286
• Form: lyophilized powder
• Assay: 97-100% (agarose gel electrophoresis)
• Biological source: human

Właściwości

• biological source: human
• Quality Segment: 200
• assay: 97-100% (agarose gel electrophoresis)
• form: lyophilized powder
• technique(s): immunofluorescence: suitable
• suitability: suitable for electrophoresis and chromatography standard
• UniProt accession no.: P69905
• storage temp.: −20°C
• Gene Information: human ... HBA2(3040)

Opis

General description

Hemoglobin A2 (HBA2) is mapped to human chromosome 16p13.3. HBA2 is a minor hemoglobin component and comprises of two α and δ chains.

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.

has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).

Application

Hemoglobin A2 was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.

Hemoglobin A2, Ferrous Stabilized human has been used as a reference in reversed-phase high-performance liquid chromatography for quantifying δ-globin elution profile. It has also been used as calibrator in isotope dilution mass spectrometry (IDMS) measurements.

Biochem/physiol Actions

Elevated levels of Hemoglobin A2 (HBA2) is observed in patients with β-thalassemia trait.

Packaging

Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).

Preparation Note

When reconstituted with buffer, gives >90% ferrous hemoglobin.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable