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G6137
Glutathione Peroxidase from bovine erythrocytes
lyophilized powder, ≥300 units/mg protein
Synonim(y):
GSH-Px, Glutathione:hydrogen-peroxide oxido-reductase
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| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
500 units | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 3080,00 zł |
Informacje o tej pozycji
Numer CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-749-6
MDL number:
Specific activity:
≥300 units/mg protein
Biological source:
bovine erythrocytes
3080,00 zł
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Pomoc techniczna
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Pozwól nam pomócbiological source
bovine erythrocytes
Quality Segment
form
lyophilized powder
specific activity
≥300 units/mg protein
mol wt
84.5 kDa
composition
Protein, 10-30% modified Warburg-Christian
shipped in
dry ice
storage temp.
−20°C
General description
Glutathione peroxidase is an antioxidant enzyme that contains selenium. It is present in the glandular epithelium of human endometrium.
Application
Glutathione peroxidase from bovine erythrocytes was used as a positive control in cloning and characterization of full-length cDNAs encoding two glutathione peroxidases (GpXs) from Globodera rostochiensis.[1] It was used for the determination of glutathione peroxidase activity in human milk.[2]
Glutathione Peroxidase from bovine erythrocytes has been used as an oxygen radical scavenger to study its effect on cytotoxicity of 1,3-dilinoleoylglycerol (DLG) against E1A-3Y1 cells.[3]
Biochem/physiol Actions
Glutathione peroxidase is an enzyme which reduced lipid hydroperoxides into their corresponding alcohols. It also reduces free hydrogen peroxide in to water. In vivo it is responsible for protecting hemoglobin from oxidative breakdown[4][5].
Protects cells against oxidative damage by catalyzing the reduction of hydrogen peroxide in the presence of reducing agent glutathione. In cellular membranes it may induce lipid peroxidation through the reduction of hydrogen peroxide or polyunsaturated fatty acid hydroperoxides.
Glutathione peroxidase helps to reduce (peroxides) H2O2 to water and lipid peroxides to lipid alcohols.
Physical form
Lyophilized powder containing 25% sucrose and 2.5% dithiothreitol with sodium phosphate buffer salts
Other Notes
Note: At the reported pH optimum of 8.8, we have found the activity to be approx. 10 times that at pH 7.0. However, to remain consistent with literature and avoid complications arising from non-enzymatic oxidation of GSH, our unit is defined at pH 7.0.
One unit will catalyze the oxidation by H2O2 of 1.0 μmole of reduced glutathione to oxidized glutathione per min at pH 7.0 at 25 °C.
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Ta pozycja | |||
|---|---|---|---|
| specific activity ≥300 units/mg protein | specific activity ≥3,000 units/mg protein | specific activity ≥4,500 units/mg protein | specific activity ≥3000 units/mg dry wt. |
| biological source bovine erythrocytes | biological source bovine erythrocytes | biological source - | biological source bovine erythrocytes |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized solid |
| shipped in dry ice | shipped in dry ice | shipped in - | shipped in ambient |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| mol wt 84.5 kDa | mol wt 32.5 kDa | mol wt 32.5 kDa | mol wt - |
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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