D4628

Diethylstilbestrol

≥99% (HPLC), Synthetic estrogen, powder

• Synonim(y): (E)-3,4-Bis(4-hydroxyphenyl)-3-hexene, DES, Stilbestrol
• Wzór empiryczny (zapis Hilla): C₁₈H₂₀O₂
• Numer CAS: 56-53-1
• Masa cząsteczkowa: 268.35
• NACRES: NA.77
• PubChem Substance ID: 24893887
• UNSPSC Code: 51111800
• EC Number: 200-278-5
• MDL number: MFCD00002373
• Beilstein/REAXYS Number: 2056095
• Assay: ≥99% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Diethylstilbestrol, ≥99% (HPLC)
• Quality Segment: 200
• assay: ≥99% (HPLC)
• form: powder
• SMILES string: CC\C(c1ccc(O)cc1)=C(\CC)c2ccc(O)cc2
• InChI: 1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+
• InChI key: RGLYKWWBQGJZGM-ISLYRVAYSA-N
• Gene Information: human ... ESR1(2099), ESR2(2100), ESRRG(2104) ; mouse ... Esr1(13982) ; rat ... Ar(24208), Esr1(24890)

Opis

Application

Diethylstilbestrol has been used:

• to evaluate the estrogenic activity of diethylstilbestrol by quantitating the expression levels of endogenous estrogen-regulated marker genes
• to evaluate the estrogenic, androgenic and toxicity responses in bioluminescent yeast bioreporter assay (BLYES)
• to detect its effect on the proliferation and tyrosinase activity of melanocytes

Biochem/physiol Actions

Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07,GHS09
• signalword: Danger
• hcodes: H315,H319,H335,H350,H360FD,H410
• pcodes: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges