This product is not assigned a firm expiration date, but lots are retested every 2 years while available to assure quality. In the original sealed container, this compound is quite stable. Exposure to light and moisture may accelerate degradation over time. A specific time frame related to the degradation rate has not been established.
Przejdź do
C9754
Colchicine
≥95% (HPLC), powder, antimitotic agent
Synonim(y):
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
Zaloguj się, aby wyświetlić ceny organizacyjne i kontraktowe.
Wybierz wielkość
Zmień widok
| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
100 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 114,00 zł |
500 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 383,00 zł |
1 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 632,00 zł |
5 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2560,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C22H25NO6
Numer CAS:
Masa cząsteczkowa:
399.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-598-5
MDL number:
Beilstein/REAXYS Number:
2228813
Assay:
≥95% (HPLC)
Form:
powder
114,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
Potrzebujesz pomocy? Nasz zespół doświadczonych naukowców chętnie Ci pomoże.
Pozwól nam pomócNazwa produktu
Colchicine, ≥95% (HPLC), powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to yellow
mp
150-160 °C (dec.) (lit.)
solubility
ethanol: 50 mg/mL
SMILES string
COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O
InChI
1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChI key
IAKHMKGGTNLKSZ-INIZCTEOSA-N
Gene Information
General description
Colchicine is a secondary metabolite, which has anti-inflammatory properties. It is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, Behçet disease, vasculitides and pericarditis. Colchicine inhibits cell division, intracellular vesicle motility, secretion of cytokines and chemokines. It is implicated in leukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space.
Application
Colchicine has been used:
- in the in vitro sister-chromatid exchange (SCE) assay
- to study its in vitro antiviral, antibacterial, antifungal and cytotoxic activities
- in microtubule disruption
- to analyse its effects on Ca2+ transients from taxol-treated cells
Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
This product in powdered format can be stored in room temperature. Colchicine powder will darken upon exposure to light. Colchicine solutions can be sterilized by autoclaving or filtration. Sterilized solutions are stable for at least six months if protected from light. No appreciable colchicine hydrolysis occurred in neutral and slightly alkaline (pH = 8.1) solutions after storage frozen for 2 months.
Ta strona może zawierać tekst przetłumaczony maszynowo.
1 of 1
Ta pozycja | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay - | assay - | assay ≥95.0% (HPLC) |
| form powder | form - | form powder | form - |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level - |
| solubility ethanol: 50 mg/mL | solubility - | solubility - | solubility - |
| color white to yellow | color - | color - | color - |
| mp 150-160 °C (dec.) (lit.) | mp 150-160 °C (dec.) (lit.) | mp 150-160 °C (dec.) (lit.) | mp 150-160 °C (dec.) (lit.) |
Still not finding the right product?
Explore all of our products under Colchicine
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Muta. 1B
Klasa składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Wykazy regulacyjne
Wykazy regulacyjne dotyczą głównie produktów chemicznych. Można w nich podawać ograniczoną liczbę informacji na temat produktów niechemicznych. Brak wpisu oznacza, że żaden ze składników nie znajduje się w wykazie. Użytkownik odpowiada za zagwarantowanie bezpiecznego i zgodnego z prawem stosowania produktu.
64-86-8
CAS No.
Wybierz jedną z najnowszych wersji:
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
-
How long is this powder stable at room temperature approximately? After how many years is appreciable degradation to be expected?
1 answer-
Helpful?
-
-
How should this colchicine be dissolved to create a solution?
1 answer-
This material is soluble in ethanol at 50 mg/mL and water at 45 mg/mL. Stock solutions may be autoclaved or filter sterilized. The compound is light sensitive. Stock solutions should be stored protected from light in amber glass bottles and are stable for at least 6 months at 2 - 8°C.
Helpful?
-
-
What is the solubility of product C9754, Colchicine? Also, what is the solution stability of Colchicine?
1 answer-
The solubility of Colchicine in DMSO is 426 mg/ml at 25 °C. It can also be dissolved in absolute ethanol (50 mg/ml), producing a clear to slightly hazy, yellow to yellow-green solution. However, this may require heat.
Regarding solution stability, Colchicine powder darkens upon exposure to light. Sterilized solutions remain stable for at least six months if shielded from light. No significant hydrolysis of colchicine occurred in neutral and slightly alkaline solutions after two months of frozen storage.
Helpful?
-
-
How should Colchicine be stored as a powder and when dissolved? At which temperature?
1 answer-
This product in powdered format can be stored in room temperature. Colchicine powder will darken upon exposure to light. Colchicine solutions can be sterilized by autoclaving or filtration. Sterilized solutions are stable for at least six months if protected from light. No appreciable colchicine hydrolysis occurred in neutral and slightly alkaline (pH = 8.1) solutions after storage frozen for 2 months.
Helpful?
-