C7555
Concanavalin A from Canavalia ensiformis (Jack bean)
agarose conjugate, Type VI, saline suspension
Synonim(y):
ConA
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5 ML
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25 ML
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100 ML
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Informacje o tej pozycji
NACRES:
NA.32
UNSPSC Code:
12161501
Form:
saline suspension
Biological source:
Canavalia ensiformis
Przejdź do
Pomoc techniczna
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Pozwól nam pomócbiological source
Canavalia ensiformis
Quality Level
conjugate
agarose conjugate
type
Type VI
form
saline suspension
extent of labeling
≥15 mg concanavalin A protein per mL
matrix
cross-linked 4% beaded agarose
matrix activation
cyanogen bromide
matrix attachment
amino
matrix spacer
1 atom
storage temp.
2-8°C
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Ta pozycja | |||
|---|---|---|---|
| biological source Canavalia ensiformis | biological source - | biological source Canavalia ensiformis | biological source - |
| form saline suspension | form lyophilized powder | form buffered aqueous suspension | form lyophilized powder |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| conjugate agarose conjugate | conjugate - | conjugate Sepharose™ conjugate | conjugate - |
| Quality Level 200 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
| matrix cross-linked 4% beaded agarose | matrix - | matrix Sepharose 4B | matrix - |
General description
Concanavalin A (Con A), isolated from Jack beans (Canavalia ensiformis), is a mannose or glucose specific-binding lectin. The lectin is a tetramer and each subunit possesses a saccharide-binding site. Con A can be isolated by affinity chromatography with dextrans.
Application
Used for the purification of glycoproteins containing mannose
Concanavalin A (Con A) has been used for enzyme immobilization.
Biochem/physiol Actions
Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.
Concanavalin A (Con A) is a T cell mitogen that can activate the lymphocytes.
Con A can induce tumor cell death through autophagy.
Con A can induce tumor cell death through autophagy.
Physical form
Suspension in 1.0 M NaCl + 0.1 M potassium phosphate, pH 6.0, with 1 mM CaCl2, 1 mM MgCl2 and 1 mM MnCl2 containing preservative
Analysis Note
Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.
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Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Klasa składowania
12 - Non Combustible Liquids
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
R Lotan et al.
Biochemistry, 16(9), 1787-1794 (1977-05-03)
The effects of several commonly used detergents on the saccharide-binding activities of lectins were investigated using lectin-mediated agglutination of formalin-fixed erythrocytes and affinity chromatography of glycoproteins on columns of lectins immobilized on polyacrylic hydrazide-Sepharose. In the hemagglutination assays, Ricinus communis
Biosensoric detection of the cysteine sulphoxide alliin
Keusgen M, et al.
Sens. Actuators, 95, 297-302 (2003)
A Kobata et al.
Journal of chromatography, 597(1-2), 111-122 (1992-04-24)
Elucidation of the binding specificity of a concanavalin A-Sepharose column led to the possibility of the affinity chromatography of oligosaccharides and glycopeptides with the use of immobilized lectin columns. Subsequent addition of immobilized erythroagglutinating phytohaemagglutinin, Aleuria aurantia lectin, Datura stramonium
Valentina Carlini et al.
The EMBO journal, 41(7), e108677-e108677 (2022-02-25)
Environmental factors can trigger cellular responses that propagate across mitosis or even generations. Perturbations to the epigenome could underpin such acquired changes, however, the extent and contexts in which modified chromatin states confer heritable memory in mammals is unclear. Here
Mai Ly Tran et al.
Traffic (Copenhagen, Denmark), 24(1), 4-19 (2022-11-19)
The trans-Golgi Network (TGN) sorts molecular "addresses" and sends newly synthesized proteins to their destination via vesicular transport carriers. Despite the functional significance of packaging processes at the TGN, the sorting of soluble proteins remains poorly understood. Recent research has
Powiązane treści
Glycobiology and Glycoproteomics Brochure
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| C7555-100ML | 04061838172334 |
| C7555-5ML | 04061838162892 |
| C7555-25ML | 04061838172341 |
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