C6499

CTB

Name: CTB
Brand: SIGMA
Price: 402 PLN

≥98% (HPLC)

Synonim(y):

CTPB, N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide

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5 MG

402,00 zł

25 MG

1080,00 zł

402,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₆H₁₃ClF₃NO₂

Numer CAS:

451491-47-7

Masa cząsteczkowa:

343.73

MDL number:

MFCD02356522

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl

InChI key

YDXZSNHARVUYNM-UHFFFAOYSA-N

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Ta pozycja	SML0302	SML1350	SML1604
Sigma-Aldrich C6499 CTB	Sigma-Aldrich SML0302 4-CMTB	Sigma-Aldrich SML1350 EPPTB	Sigma-Aldrich SML1604 NDB
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >10 mg/mL	solubility DMSO: ≥10 mg/mL	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 10 mg/mL, clear
color white to off-white	color white to beige	color white to beige	color white to beige

General description

CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.

Application

CTB has been used to study its apoptotic effects on P53 protein acetylation.

Biochem/physiol Actions

CBP (CREB binding protein)/p300) histone acetyltransferases (HATs) activator; p300 HAT activator.

CTPB was a first known small molecular activator of histone acetyltransferase p300. CTB is a simplified analog of CTPB with comparable or higher activity. The compound activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein.

Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Klasa składowania

11 - Combustible Solids

wgk

WGK 2

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Certyfikaty analizy (CoA)

Lot/Batch Number

0000139964

0000188878

0000125192

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In renovascular hypertension, TNF-α type-1 receptors in the area postrema mediate increases in cardiac and renal sympathetic nerve activity and blood pressure.

Willian S Korim et al.

Cardiovascular research, 115(6), 1092-1101 (2018-10-26)

Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is evidence that increased release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α) contributes to the development of the hypertension, but the underlying neural mechanisms are

Post-mortem mechanical injection of low quality beef loins with pork back fat improves palatability and sensory attributes.

DeMetris D Reed et al.

Meat science, 123, 205-210 (2016-10-19)

Palatability attributes of beef striploin steaks mechanically enhanced with pork fat were evaluated. Striploins were collected from USDA Standard steer carcasses, longitudinally cut into halves (lateral or medial) and assigned randomly to pork fat injection (PFI) or non-injected control (CON).

Neuroprotective Effects of Exercise on the Morphology of Somatic Motoneurons Following the Death of Neighboring Motoneurons.

Cory Chew et al.

Neurorehabilitation and neural repair, 33(8), 656-667 (2019-07-10)

Background. Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. We have previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in nearby surviving motoneurons, and

The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines

Dastjerdi MN, et al.

Advanced Biomedical Research, 2 (2013)

Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss.

Franklin D Echevarria et al.

Frontiers in neuroscience, 11, 318-318 (2017-06-18)

The pleotropic cytokine interleukin-6 (IL-6) is implicated in retinal ganglion cell (RGC) survival and degeneration, including that associated with glaucoma. IL-6 protects RGCs from pressure-induced apoptosis

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Produkty

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Numer pozycji handlu globalnego

SKU	NUMER GTIN
C6499-25MG	04061832631868
C6499-5MG	04061832631875

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