This product is sold as a white, photosensitive solid. The data sheet indicates solubility is 2.5 g/mL in water or 300 mg/mL in ethanol. No information is available regarding solution stability after solubilizing the cocaine. A certified reference standard is available as product C1528, with a concentration of 1 mg/mL in methanol. The recommended storage temperature for this product is 2-8 °C. A random Certificate of Analysis shows the product has a 3-year expiration date from the date of quality release.
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C5776
Cocaine hydrochloride
CNS stimulator, powder
Synonim(y):
Ecgonine methyl ester benzoate hydrochloride
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C17H21NO4 · HCl
Numer CAS:
Masa cząsteczkowa:
339.81
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-167-1
MDL number:
Form:
powder
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Pozwól nam pomócNazwa produktu
Cocaine hydrochloride,
form
powder
Quality Segment
drug control
USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal), kontrollierte Droge in Deutschland
application(s)
forensics and toxicology
SMILES string
Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3
InChI
1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1
InChI key
PIQVDUKEQYOJNR-VZXSFKIWSA-N
Application
Cocaine hydrochloride has been used:
- in saline control to study the effects of cocaine self-administration in mouse brain[1]
- as adopamine (DA), noradrenaline (NA), and serotonin (5-HT) reuptake inhibitor to evoke neurotransmitter release in artificial fish cerebrospinal fluid (aCSF)[2]
- to examine conditioning to intravenous cocaine hydrochloride[3]
Biochem/physiol Actions
Inhibits the dopamine, norepinephrine, and serotonin transporters with Kis of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.
Inhibits the dopamine, norepinephrine, and serotonin transporters.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3
target_organs
Central nervous system
Klasa składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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I wonder that if I dissolve the cocaine in saline, is it stable for long term? Should I storage it in -20 or 4? For how long?
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