BM0015

BMS-309403

≥98% (HPLC)

• Synonim(y): 2-[[2′-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1′-biphenyl]-3-yl]oxy]acetic acid, BMS 309403
• Wzór empiryczny (zapis Hilla): C₃₁H₂₆N₂O₃
• Numer CAS: 300657-03-8
• Masa cząsteczkowa: 474.55
• Numer MDL: MFCD09991687
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329774359
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Postać: powder
• kolor: white to beige
• rozpuszczalność: DMSO: 10 mg/mL, clear
• temp. przechowywania: room temp
• ciąg SMILES: O=C(O)COC1=CC(C2=CC=CC=C2N3C(CC)=C(C4=CC=CC=C4)C(C5=CC=CC=C5)=N3)=CC=C1

Opis

Działania biochem./fizjol.

BMS-309403 is a potent and selective inhibitor of fatty acid binding protein 4 (FABP4), also known as adipocyte FABP (A-FABP, aP2). FABP4 is an intracellular lipid-binding protein responsible for the transportation of fatty acids. It is expressed primarily in adipose tissue and is associated with inflammation, obesity, diabetes and cardiovascular diseases. BMS309403 interacts with the fatty-acid-binding pocket within the interior of FABP4 and has been shown to competitively inhibit fatty acid binding with a Ki value < 2 nM. BMS309403 is orally active and has been shown to reduce atherosclerosis in mice studies.

Cechy i korzyści

BMS-309403 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Informacje prawne

Sold for research purposes only under agreement from BMS.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 13 - Non Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable