B9935

BMS-345541

Name: BMS-345541
Brand: SIGMA
Price: 1020 PLN

≥98% (HPLC), powder

Synonim(y):

N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride

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5 MG

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₄H₁₇N₅ · HCl

Numer CAS:

547757-23-3

Masa cząsteczkowa:

291.78

NACRES:

NA.77

PubChem Substance ID:

24724429

UNSPSC Code:

12352200

MDL number:

MFCD07784499

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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InChI key

MIDKPVLYXNLFGZ-UHFFFAOYSA-N

SMILES string

Cl[H].Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1

InChI

1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

DMSO: 18 mg/mL, H₂O: insoluble

originator

Bristol-Myers Squibb

storage temp.

2-8°C

Quality Level

100

Powiązane kategorie

Bioactive Small Molecule Inhibitors

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Ta pozycja	SML2410	SML2331	SML2551
Sigma-Aldrich B9935 BMS-345541	Sigma-Aldrich SML2410 ABC99	Sigma-Aldrich SML2331 Perospirone hydrochloride	Sigma-Aldrich SML2551 AZ32
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level -	Quality Level -	Quality Level -
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 18 mg/mL, H₂O: insoluble	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear
storage condition desiccated	storage condition -	storage condition desiccated	storage condition -

Application

BMS-345541 has been used:

as an IκB kinase (IKK) complex inhibitor to study its effects on the interferon-γ (IFN-γ) production by natural killer (NK) cells[1]
as an IKK inhibitor to study its effects on the expression of eotaxin and monocyte chemoattractant protein-1 (MCP-1) mRNA in gingival fibroblasts[2]
as nuclear factor κB (NF-κB) pathway inhibitor to study its effects on tumor necrosis factor α (TNFα) production in human oral squamous carcinoma cells[3]

Biochem/physiol Actions

BMS-345541 is an IKB kinase (IKK) allosteric site inhibitor.

BMS-345541 possesses anti-inflammatory properties.[4] It also blocks the nuclear factor κB (NF-κB)-dependent transcription of pro-inflammatory cytokines.[5] BMS-345541 possesses anti-inflammatory activity and plays a role in arresting bone erosion in certain animal models.[2]

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis.

Neety Sahu et al.

JCI insight, 7(20) (2022-10-05)

No disease-modifying drug exists for osteoarthritis (OA). Despite success in animal models, candidate drugs continue to fail in clinical trials owing to the unmapped interpatient heterogeneity and disease complexity. We used a single-cell platform based on cytometry by time-of-flight (cyTOF)

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice.

James R Burke et al.

The Journal of biological chemistry, 278(3), 1450-1456 (2002-10-31)

The signal-inducible phosphorylation of serines 32 and 36 of I kappa B alpha is critical in regulating the subsequent ubiquitination and proteolysis of I kappa B alpha, which then releases NF-kappa B to promote gene transcription. The multisubunit I kappa

NF-κB inhibitors impair lung epithelial tight junctions in the absence of inflammation.

Christina Ward et al.

Tissue barriers, 3(1-2), e982424-e982424 (2015-04-04)

NF-κB (p50/p65) is the best characterized transcription factor known to regulate cell responses to inflammation. However, NF-κB is also constitutively expressed. We used inhibitors of the classical NF-κB signaling pathway to determine whether this transcription factor has a role in

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.

Zhiyang Chen et al.

The Journal of experimental medicine, 216(1), 152-175 (2018-12-12)

Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enhances their

TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8.

Aminah Ikner et al.

The Journal of biological chemistry, 286(24), 21546-21554 (2011-04-29)

The tumor necrosis factor (TNF) superfamily member TNF-like weak inducer of apoptosis (TNFSF12, CD255) (TWEAK) can stimulate apoptosis in certain cancer cells. Previous studies suggest that TWEAK activates cell death indirectly, by inducing TNFα-mediated autocrine signals. However, the underlying death-signaling

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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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BMS-345541

≥98% (HPLC), powder

Wybierz wielkość

B9935-5MG

1020,00 zł

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Właściwości

InChI key

SMILES string

InChI

assay

form

storage condition

solubility

originator

storage temp.

Quality Level

Powiązane kategorie

Porównaj podobne pozycje

Ta pozycja

Opis

Application

Biochem/physiol Actions

Features and Benefits

Informacja o środkach bezpieczeństwa

Klasa składowania

wgk

flash_point_f

flash_point_c

ppe

Dokumentacja

Certyfikaty analizy (CoA)

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