A8861

Aceclofenac

≥98% (HPLC), anti-inflammatory drug, powder

• Synonim(y): 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;
• Wzór empiryczny (zapis Hilla): C₁₆H₁₃Cl₂NO₄
• Numer CAS: 89796-99-6
• Masa cząsteczkowa: 354.18
• UNSPSC Code: 12352200
• PubChem Substance ID: 329771021
• NACRES: NA.77
• MDL number: MFCD00864296
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Aceclofenac, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: off-white to light tan
• solubility: DMSO: ≥20 mg/mL
• storage temp.: room temp
• SMILES string: OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
• InChI: 1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)
• InChI key: MNIPYSSQXLZQLJ-UHFFFAOYSA-N
• Gene Information: human ... PTGS2(5743)

Opis

Application

Aceclofenac (ACE) has been used as an internal standard in the in vivo blood-brain barrier assay.[1] It has also been used to study the interaction of ACE with bovine serum albumin (BSA) by using spectroscopic techniques in combination with computational methods.[2]

Biochem/physiol Actions

Aceclofenac is a phenyl acetic acid derivative used for treating symptoms like swelling, tenderness, and stiffness due to muscle-skeletal and bone-related diseases (rheumatoid arthritis, juvenile arthritis, osteoarthritis, and acute gouty arthritis). This compound shows analgesic and antipyretic properties. Aceclofenac suppresses prostaglandin biosynthesis.[2]

Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301,H319,H410
• pcodes: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable