477R-1

MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody

• Synonim(y): Melanoma-associated antigen C2
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: EP405, monoclonal
• Application: IHC (p)
• Citations: 7

Właściwości

• biological source: rabbit
• Quality Segment: 100, 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP405, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (477R-14), vial of 0.1 mL concentrate Research Use Only (477R-14-RUO), vial of 0.5 mL concentrate (477R-15), vial of 1.0 mL concentrate (477R-16), vial of 1.0 mL concentrate Research Use Only (477R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (477R-17), vial of 7.0 mL pre-dilute ready-to-use (477R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• isotype: IgG
• control: seminoma
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear

Opis

General description

Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.^1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.⁴ In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.^5-7

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• wgk: WGK 2