358R-1

MUM1 (EP190) Rabbit Monoclonal Primary Antibody

• Synonim(y): Multiple Myeloma Oncogene-1
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: EP190, monoclonal
• Application: IHC (p)
• Citations: 12

Właściwości

• biological source: rabbit
• Quality Segment: 100, 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP190, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (358R-14), vial of 0.1 mL concentrate Research Use Only (358R-14-RUO), vial of 0.5 mL concentrate (358R-15), vial of 1.0 mL concentrate (358R-16), vial of 1.0 mL concentrate Research Use Only (358R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (358R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (358R-17), vial of 7.0 mL pre-dilute ready-to-use (358R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (358R-18-RUO)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
• isotype: IgG
• control: diffuse large B-cell (lymphoma), plasma cell myeloma (tumor), tonsil
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic, nuclear
• Gene Information: human ... PWWP3A(84939)

Opis

General description

Anti-MUM1 antibody labels a 50kDa, multiple myeloma oncogene-1 (MUM1) protein. MUM1 is encoded by the MUM1/IRF-4 gene, which is mapped to 6q23-25 and identified as a myeloma-associated oncogene.[1][2] It is a member of the interferon regulatory factor family of transcription factors and plays an important role in the regulation of gene expression in response to signaling by interferon and other cytokines. MUM1 positive cells express the protein in the nucleus in a diffuse and microgranular pattern. However, some positivity is also observed in the cytoplasm of MUM1-expressing cells. In normal/reactive lymphoid tissues, such as lymph node, this antibody stains plasma cells, some B-cells in the light zone of germinal centers, and a subset of T-cells (T-cells in germinal centers and interfollicular areas).[1][2] MUM1 expression has been described in diffuse large B-cell lymphoma (DLBCL).[3] Anti-MUM1 antibody can stain other B-cell lymphomas such as lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, lymphoblastic lymphoma/leukemia, primary effusion lymphoma, DLBCL, Burkitt-like lymphoma, and classical Hodgkin lymphoma.[4][3][5] However, the tumor cells in nodular lymphocyte predominant Hodgkin lymphoma are negative or only weakly positive.[6] MUM1 is also expressed in plasma cell myeloma.[7]

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

IVD

IVD

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

MUM1 Positive Control Slides, Product No. 358S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable