PHR3029

Lomustine

pharmaceutical secondary standard, certified reference material

• Synonim(y): Lomustine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
• Wzór empiryczny (zapis Hilla): C₉H₁₆ClN₃O₂
• Numer CAS: 13010-47-4
• Masa cząsteczkowa: 233.70
• UNSPSC Code: 41116107
• NACRES: NA.24
• MDL number: MFCD00012392

Właściwości

• Quality Segment: 300
• grade: certified reference material, pharmaceutical secondary standard
• agency: traceable to USP 1369419
• API family: lomustine
• CofA: current certificate can be downloaded
• packaging: pkg of 500 mg
• application(s): pharmaceutical
• storage temp.: 2-8°C
• SMILES string: ClCCN(N=O)C(=O)NC1CCCCC1
• InChI: 1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
• InChI key: GQYIWUVLTXOXAJ-UHFFFAOYSA-N

Opis

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Lomustine can be used in quantitative determination of analyte in rat plasma using HPLC/UV) method. It can also be used as a reference standard in the determination of lomustine capsules.

Biochem/physiol Actions

Antineoplastic agent with cellular DNA effects. Lomustine induces p53 expression in A2870 cells.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H350
• pcodes: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 1B
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable