PHR1909

Atenolol

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonim(y): Atenolol, (±)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide, 4-[2′-Hydroxy-3′-(isopropylamino)propoxy]phenylacetamide
• Wzór empiryczny (zapis Hilla): C₁₄H₂₂N₂O₃
• Numer CAS: 29122-68-7
• Masa cząsteczkowa: 266.34
• UNSPSC Code: 41116107
• NACRES: NA.24
• EC Number: 249-451-7
• MDL number: MFCD00057645

Właściwości

• Quality Segment: 300
• grade: certified reference material, pharmaceutical secondary standard
• agency: traceable to Ph. Eur. A1340000, traceable to USP 1044403
• API family: atenolol
• form: powder
• CofA: current certificate can be downloaded
• packaging: pkg of 500 mg
• application(s): pharmaceutical
• storage temp.: 2-30°C
• SMILES string: CC(C)NCC(O)COc1ccc(CC(N)=O)cc1
• InChI: 1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
• InChI key: METKIMKYRPQLGS-UHFFFAOYSA-N
• Gene Information: human ... ADRB1(153)

Opis

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Atenolol is a beta-1 blocker used in the treatment of various cardiovascular diseases.

Application

This pharmaceutical secondary standard can also be used as follows:

• Simultaneous analysis of atenolol and nifedipine using magnesium oxide-nanoplatelets (MgO-NPLs) modified screen-printed electrodes (SPEs) by differential pulse voltammetry (DPV) from pharmaceutical dosage forms and urine samples
• Voltammetric determination of amlodipine besylate and atenolol in their combined pharmaceutical formulations using a cathodically pretreated-boron doped diamond electrode (CP-BDDE)
• Spectrofluorimetric determination of atenolol using gold nanoparticles (AuNPs) based photo probes in commercial tablets
• Amperometric estimation of atenolol using bismuth vanadate-bismuth(III) oxide (BiVO₄–Bi₂O) composite electrode in pharmaceutical formulations and human urine samples
• Development of a reversed phase-high performance liquid chromatography (RP-HPLC) method coupled to a photodiode array detector (PDA) for the quantitative analysis of atenolol and trimetazidine in human urine and pharmaceutical tablets

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

To see an example of a Certificate of Analysis for this material enter LRAC0712 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable