According to literature research, a 10 mg/kg intraperitoneal (IP) injection of Celecoxib in mice can utilize several vehicle formulations to manage its high hydrophobicity and low aqueous solubility.
DMSO/Tween/Methylcellulose Mix: A common protocol involves dissolving Celecoxib in 10% DMSO, then further diluting it with 0.5% methylcellulose containing 0.025% Tween 80.
DMSO and Saline: Celecoxib can be dissolved in a vehicle consisting of 10% DMSO in normal saline.
Complex Solvent Blend: A more sophisticated vehicle used for pharmacokinetics in mice is 20% DMSO / 10% (DMSO/Cremophor EL 1:1) / 70% H?O, which reportedly shows no adverse reactions.
The following papers can be used as references:
Lu et al. (2013)
Wiese et al. (2018)
Khayyat et al. (2020)
Przejdź do
PHR1683
Celecoxib
Pharmaceutical Secondary Standard; Certified Reference Material
Synonim(y):
Celecoxib, 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide, CJ-016377, CP-598107, PF-00345549, PHA-00846533, SC-58635, YM-177
Wybierz wielkość
| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
1 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 733,00 zł |
Informacje o tej pozycji
733,00 zł
Quality Segment
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0001445, traceable to USP
API family
celecoxib
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
Cc1ccc(cc1)-c2cc(nn2-c3ccc(cc3)S(N)(=O)=O)C(F)(F)F
InChI
1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
InChI key
RZEKVGVHFLEQIL-UHFFFAOYSA-N
Gene Information
human ... PTGS2(5743)
General description
Application
Biochem/physiol Actions
Analysis Note
Other Notes
1 of 1
Ta pozycja | |||
|---|---|---|---|
| description Pharmaceutical Secondary Standard; Certified Reference Material | description United States Pharmacopeia (USP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard | description British Pharmacopoeia (BP) Reference Standard |
| application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical |
| technique(s) gas chromatography (GC): suitable, HPLC: suitable | technique(s) - | technique(s) - | technique(s) - |
| format neat | format neat | format neat | format neat |
| Quality Level 300 | Quality Level - | Quality Level - | Quality Level 100 |
| grade certified reference material, pharmaceutical secondary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard |
| storage temp. 2-30°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
Still not finding the right product?
Explore all of our products under Celecoxib
Słowo ostrzegawcze
Danger
Kody zagrożeń
Hazard Classifications
Aquatic Chronic 1 - Repr. 1B - STOT RE 2
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Co się dzieje?
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Wybierz jedną z najnowszych wersji:
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
-
For my experiments, I should deliver Celecoxib via intraperitoneal injection in adult mice (dose 10mg/kg). I would like to know the suggested vehicle in which Celecoxib should be diluted. Do you have any suggestions or papers to share with me?
1 answer-
Helpful?
-
-
How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
-
-
How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
-