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PHR1271

Levodopa

Pharmaceutical Secondary Standard; Certified Reference Material

Synonim(y):

3,4-Dihydroxy-L-phenylalanine, 3-(3,4-Dihydroxyphenyl)-L-alanine, L-3-Hydroxytyrosine, L-DOPA, Levodopa

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Rozmiar/SKUDostępnośćCena netto
500 mg
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645,00 zł

Informacje o tej pozycji

Wzór liniowy:
(HO)2C6H3CH2CH(NH2)CO2H
Numer CAS:
Masa cząsteczkowa:
197.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-445-2
Beilstein/REAXYS Number:
2215169
MDL number:
eCl@ss:
32160406

645,00 zł


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Quality Segment

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. L0400000, traceable to USP 1361009

API family

levodopa

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

276-278 °C (lit.)

application(s)

pharmaceutical
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O

InChI

1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

InChI key

WTDRDQBEARUVNC-LURJTMIESA-N

Gene Information

human ... DRD3(1814)

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Levodopa is a metabolic precursor of the neurotransmitter dopamine and is widely used in the treatment of Parkinson′s disease.

Application

Levodopa may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using flow injection spectrophotometric method and 1H nuclear magnetic resonance spectroscopy.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2957 in the slot below. This is an example certificate only and may not be the lot that you receive.
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Ta pozycja
BP213L0400000D9628
Levodopa Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1271

Levodopa

Levodopa British Pharmacopoeia (BP) Reference Standard

BP213

Levodopa

Levodopa European Pharmacopoeia (EP) Reference Standard

L0400000

Levodopa

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

British Pharmacopoeia (BP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

≥98% (TLC)

technique(s)

gas chromatography (GC): suitable, HPLC: suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

pharmaceutical (small molecule)

application(s)

peptide synthesis

format

neat

format

neat

format

neat

format

-

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

200

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp


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Piktogramy

Exclamation mark

Słowo ostrzegawcze

Warning

Kody zagrożeń

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Narządy docelowe

Respiratory system

Klasa składowania

11 - Combustible Solids

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable



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Certyfikaty analizy (CoA)

Lot/Batch Number

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Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. For how long should you store L-DOPA after elution?

    1 answer
    1. As a neat material stored at a refrigerated temperature and protected from light, levodopa is stable for at least 3 years. Levodopa is not stable in solution for long durations. According to peer-reviewed literature, levodopa degrades significantly in solution at ambient temperature over the course of 48 hours. The addition of a reducing agent such as ascorbate can prolong solution stability up to 72 hours. Refrigeration or freezing of the solution can significantly reduce levodopa degradation for up to 7 days. In general, it is recommended to prepare a solution of levodopa the day it is needed.

      Helpful?

  4. What is the best solvent that dissolves this product? To prepare the stock solution

    1 answer
    1. It is soluble in water (3 mg/ml), DMSO (<1 mg/ml at 25° C), and 0.5M HCl (50 mg/ml).

      Helpful?

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