PHR1108

L-Histidine

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonim(y): (S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
• Wzór empiryczny (zapis Hilla): C₆H₉N₃O₂
• Numer CAS: 71-00-1
• Masa cząsteczkowa: 155.15
• NACRES: NA.24
• PubChem Substance ID: 329823130
• eCl@ss: 32160406
• UNSPSC Code: 41116107
• EC Number: 200-745-3
• MDL number: MFCD00064315
• Beilstein/REAXYS Number: 84088

Właściwości

• Quality Segment: 300
• grade: certified reference material, pharmaceutical secondary standard
• agency: traceable to Ph. Eur. H0750000, traceable to USP 1308505
• API family: histidine
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• mp: 282 °C (dec.) (lit.)
• application(s): cleaning products; cosmetics; flavors and fragrances; food and beverages; personal care; pharmaceutical (small molecule); pharmaceutical
• format: neat
• storage temp.: 2-30°C
• SMILES string: N[C@@H](Cc1c[nH]cn1)C(O)=O
• InChI: 1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
• InChI key: HNDVDQJCIGZPNO-YFKPBYRVSA-N

Opis

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-Histidine is an essential amino acid, widely present at the active sites of enzymes. It binds to metal ions and may aid in the transport of copper. It also plays an important role for the binding of heme groups, macromolecules and phosphate groups in the binding sites of proteins.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Precursor of histamine by action of histidine decarboxylase.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA7159 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable