90833

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid

analytical standard

• Synonim(y): 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid, CMPF, Propylurofuranic acid
• Wzór empiryczny (zapis Hilla): C₁₂H₁₆O₅
• Numer CAS: 86879-39-2
• Masa cząsteczkowa: 240.25
• Numer MDL: MFCD08436079
• Kod UNSPSC: 12352106
• NACRES: NB.21

Właściwości

• klasa czystości: analytical standard
• Poziom jakości: 100
• Próba: ≥95.0% (HPLC)
• okres trwałości: limited shelf life, expiry date on the label
• Zastosowanie: clinical testing
• Format: neat
• temp. przechowywania: 2-8°C
• ciąg SMILES: OC(CCC1=C(C(O)=O)C(C)=C(CCC)O1)=O
• InChI: 1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16)
• Klucz InChI: WMCQWXZMVIETAO-UHFFFAOYSA-N

Opis

Opis ogólny

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), a major metabolite of furan fatty acids,[1][2] is a uremic toxin (UT), excreted into the urine via organic,anion transporters under physiological conditions.[2] It is mostly reported to be accumulated in chronic kidney disease (CKD) patients.[3] Monitoring of CMPF may be important to predict organic anion transporting polypeptide (OATP)1B activity in CKD patients as studies have implicated a decreased trend in (OATP)1B activity in patients with this uremic toxin.[3] It is also found to be in increased concentrations, for patients who progress from prediabetes to type 2 diabetes, patients with renal failure, polyunsaturated fatty acids with high-temperature cooking and subjects who consume fish or fish oil.[1][2]

Zastosowanie

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid may be used as an analytical reference standard for the quantification of the analyte in human plasma samples using ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS).[3]

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3