90833

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid

analytical standard

• Synonim(y): 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid, CMPF, Propylurofuranic acid
• Wzór empiryczny (zapis Hilla): C₁₂H₁₆O₅
• Numer CAS: 86879-39-2
• Masa cząsteczkowa: 240.25
• UNSPSC Code: 12352106
• NACRES: NB.21
• MDL number: MFCD08436079

Właściwości

• grade: analytical standard
• Quality Segment: 100
• assay: ≥95.0% (HPLC)
• shelf life: limited shelf life, expiry date on the label
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• SMILES string: OC(CCC1=C(C(O)=O)C(C)=C(CCC)O1)=O
• InChI: 1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16)
• InChI key: WMCQWXZMVIETAO-UHFFFAOYSA-N

Opis

General description

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), a major metabolite of furan fatty acids, is a uremic toxin (UT), excreted into the urine via organic,anion transporters under physiological conditions. It is mostly reported to be accumulated in chronic kidney disease (CKD) patients. Monitoring of CMPF may be important to predict organic anion transporting polypeptide (OATP)1B activity in CKD patients as studies have implicated a decreased trend in (OATP)1B activity in patients with this uremic toxin. It is also found to be in increased concentrations, for patients who progress from prediabetes to type 2 diabetes, patients with renal failure, polyunsaturated fatty acids with high-temperature cooking and subjects who consume fish or fish oil.

Application

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid may be used as an analytical reference standard for the quantification of the analyte in human plasma samples using ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS).

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3