901990

Tetrazine-acid

• Synonim(y): 4-(1,2,4,5-Tetrazin-3-yl)benzeneacetic acid
• Wzór empiryczny (zapis Hilla): C₁₀H₈N₄O₂
• Numer CAS: 1380500-92-4
• Masa cząsteczkowa: 216.20
• UNSPSC Code: 12352106
• NACRES: NA.22
• MDL number: MFCD24503098

Właściwości

• form: powder or crystals
• availability: available only in USA
• storage temp.: −20°C
• SMILES string: n1ncnnc1c2ccc(cc2)CC(=O)O
• InChI: 1S/C10H8N4O2/c15-9(16)5-7-1-3-8(4-2-7)10-13-11-6-12-14-10/h1-4,6H,5H2,(H,15,16)
• InChI key: SLJKKTFIAUAYGR-UHFFFAOYSA-N

Opis

Application

Tetrazine-acid demonstrates exceptionally fast cycloaddition kinetics with trans-cyclooctene (TCO) as the dienophile (up to 30,000 M^-1 s^-1). These have been the fastest kinetics reported for a bio orthogonal reaction. The chemical stability of tetrazines is substantially lower compared to methyltetrazines, thus requiring more careful selection of reagents and conditions for chemical transformation. However, tetrazine chemistry is still in an acceptable range for many applications.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS02
• signalword: Danger
• hcodes: H242
• pcodes: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Klasa składowania: 5.2 - Organic peroxides and self-reacting hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable