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Dokumenty

46665

Supelco

Progesterone

VETRANAL®, analytical standard

Synonim(y):

4-Pregnene-3,20-dione

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About This Item

Wzór empiryczny (zapis Hilla):
C21H30O2
Numer CAS:
57-83-0
Masa cząsteczkowa:
314.46
Beilstein:
1915950
Numer WE:
200-350-6
Numer MDL:
MFCD00003658
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329756616
NACRES:
NA.24

klasa czystości

analytical standard

Poziom jakości

100

linia produktu

VETRANAL®

Próba

99.5% (HPLC)

okres trwałości

limited shelf life, expiry date on the label

metody

HPLC: suitable
gas chromatography (GC): suitable

mp

128-132 °C (lit.)

Zastosowanie

pharmaceutical (small molecule)

format

neat

ciąg SMILES

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

Klucz InChI

RJKFOVLPORLFTN-LEKSSAKUSA-N

informacje o genach

human ... ESR1(2099) , PGR(5241)

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Zastosowanie

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Działania biochem./fizjol.

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Inne uwagi

Steroid hormone produced by the corpus luteum.

Informacje prawne

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
This page may contain text that has been machine translated.

Piktogramy

Health hazard
GHS08

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H351,H360FD,H362

Zwroty wskazujące środki ostrożności

P202 - P260 - P263 - P264 - P280 - P308 + P313

Klasyfikacja zagrożeń

Carc. 2 - Lact. - Repr. 1A

Kod klasy składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certyfikaty analizy (CoA)

Lot/Batch Number
BCCK4203
BCBZ9566
SZBE164XV
SZBD333XV
SZBA321XV

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Rudolf Kaaks et al.
International journal of cancer, 134(8), 1947-1957 (2013-10-25)
Results from prospective studies on premenopausal serum hormone levels in relation to breast cancer risk have been inconclusive, especially with regard to tumor subtypes. Using a case-control study nested within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC)
Brett E Skolnick et al.
The New England journal of medicine, 371(26), 2467-2476 (2014-12-11)
Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. We investigated the efficacy and safety of progesterone in a large, prospective, phase
Danijela Konforte et al.
Clinical chemistry, 59(8), 1215-1227 (2013-05-03)
Pediatric endocrinopathies are commonly diagnosed and monitored by measuring hormones of the hypothalamic-pituitary-gonadal axis. Because growth and development can markedly influence normal circulating concentrations of fertility hormones, accurate reference intervals established on the basis of a healthy, nonhospitalized pediatric population
Xiaofei Sun et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(5), 2380-2389 (2014-01-29)
Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is expressed in many organs, including female reproductive organs, and is a stem cell marker in the stomach and intestinal epithelium, hair follicles, and ovarian surface epithelium. Despite ongoing studies, the definitive physiological functions
Cathrin Brisken
Nature reviews. Cancer, 13(6), 385-396 (2013-05-25)
Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase
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